激素治疗Graves病合并上呼吸道感染后发生急性胆汁淤积性黄疸1例  

A case of acute cholestatic jaundice after hormone treatment of Graves disease with upper respiratory tract infection

作　　者：夏保田 刁宏翠 逄曙光[2] Xia Baotian;Diao Hongcui;Pang Shuguang(School of Clinical Medicine,Weifang Medical University,Weifnag 261053,China;Department of Endocrinology,Jinan Central Hospital,Shandong University&Jinan Central Hospital Affiliated to Shandong First Medical University,Jinan 250013,China)

机构地区：[1]潍坊医学院临床医学院,潍坊261053 [2]山东大学济南市中心医院、山东第一医科大学附属济南市中心医院内分泌科,济南250013

出　　处：《中国综合临床》2023年第1期61-63,共3页Clinical Medicine of China

摘　　要：胆汁淤积性黄疸在Graves病患者中并不多见,通常被认为是Graves病的并发症或甲巯咪唑的不良反应。我们报道1例来自济南市中心医院的Graves病合并上呼吸道感染后出现急性胆汁淤积性黄疸患者,经过及时的糖皮质激素治疗后,患者黄疸快速消退,肝功能逐渐恢复正常。我们认为Graves病合并上呼吸道感染可导致胆汁淤积性黄疸的发生,其发病机制可能是免疫功能紊乱,而糖皮质激素治疗有利于黄疸的消退。Cholestatic jaundice is rare in patients with Graves'disease and is generally considered to be a complication of Graves'disease or an adverse reaction to methimazole.We report a case of acute cholestatic jaundice caused by Graves'disease complicated with upper respiratory tract infection in Jinan Central Hospital.After timely treatment with glucocorticoid,the jaundice quickly subsided and the liver function gradually returned to normal.We believe that Graves'disease combined with upper respiratory tract infection can lead to cholestatic jaundice,the pathogenesis of which may be immune dysfunction,and glucocorticoid therapy is beneficial to the regression of jaundice.

关 键 词：GRAVES病 上呼吸道感染 胆汁淤积性黄疸 糖皮质激素 

分 类 号：R581.1[医药卫生—内分泌] R56[医药卫生—内科学] R575[医药卫生—临床医学]