妊娠合并原发性甲状旁腺功能亢进症3例  

Pregnancy complicated with primary hyperparathyroidism:a report of 3 cases

作　　者：葛子琦 张子笠 杨秋红[1] 李燕 李晓平[1] 宋敏[1] Ge Ziqi;Zhang Zili;Yang Qiuhong;Li Yan;Li Xiaoping;Song Min(Department of Obstetrics,Jinan Maternity and Child Care Hospital,Jinan 250218,China;Department of Thyroid and Breast Surgery,the Fourth People′s Hospital of Jinan,Jinan 250031,China)

机构地区：[1]济南市妇幼保健院产科,济南250218 [2]济南市第四人民医院甲状腺与乳腺外科,济南250031

出　　处：《中华全科医师杂志》2023年第2期194-196,共3页Chinese Journal of General Practitioners

摘　　要：回顾性分析2013—2021年济南市妇幼保健院收治的3例妊娠合并原发性甲状旁腺功能亢进症患者资料。3例均在妊娠期确诊,临床表现以恶心、呕吐、食欲减退、乏力等非特异性表现为主;均有高血钙危象,血清钙分别为4.11、2.92~3.82、3.49~4.10 mmol/L,其中2例发生子痫前期;1例有胆囊结石、1例有胆囊息肉,2例均有肾实质改变。例1孕期未行血清钙检测,35周+3并血压升高1 d入院,入院后突发呼吸、心跳停止积极抢救后死亡;例2妊娠期积极控制血钙,新生儿出现低钙血症,预后良好;例3于妊娠早期行手术治疗,后出现稽留流产。例1尸检确定诊断,另2例病理检查均提示甲状旁腺肿瘤。Clinical data of 3 pregnant women with primary hyperparathyroidism admitted in Jinan Maternal and Child Health Hospital from 2013 to 2021 were retrospectively reviewed.Hyperparathyroidism was diagnosed during pregnancy in all 3 cases.The clinical manifestations were non-specific,such as nausea,vomiting,anorexia,and fatigue.Patients also had gallbladder stones(1 case),gallbladder polyps(1 case),and renal parenchyma changes(2 cases).The hypercalcemia crisis occurred in all 3 cases,the blood Ca2+levels were 4.11 mmol/L,2.92-3.82 mmol/L and 3.49-4.10 mmol/L,respectively;and preeclampsia developed in 2 cases.Sudden death occurred in case 1 who did not receive effective treatment during pregnancy;blood calcium was well controlled during pregnancy in case 2,and her neonate had hypocalcemia with good prognosis;case 3 underwent surgical treatment in early pregnancy,and then had missed abortion.Pathological examination revealed parathyroid tumors in all 3 cases.

关 键 词：原发性甲状旁腺功能亢进症 高钙血症 妊娠期 

分 类 号：R714.256[医药卫生—妇产科学]