Optimization of the Formulation Process of Glucosamine Chondroitin Sulfate Tablets  

作　　者：Jingkun XU Donghai CHU 

机构地区：[1]Xuzhou Vocational College of Industrial Technology,Xuzhou 221140,China [2]Liaoning Institute of Science and Technology,Benxi 117400,China

出　　处：《Agricultural Biotechnology》2023年第1期94-97,共4页农业生物技术（英文版）

基　　金：Supported by School-level High-level Talent Project (XGY2021A022);Doctoral Research Startup Fund of Department of Science&Technology of Liaoning Province (2021-BS-252)。

摘　　要：[Objectives]This study was conducted to optimize the Formulation Process of glucosamine chondroitin sulfate tablets. [Methods] The orthogonal design with three levels was carried out with microcrystalline cellulose, calcium hydrophosphate and cross-linked polyvinylpyrrolidone as three factors to optimize the preparation process. [Results] When microcrystalline cellulose 200 mg/tablet, calcium hydrophosphate 150 mg/tablet, and cross-linked polyvinylpyrrolidone 80 mg/tablet were added, the angle of repose could meet the requirements of tablet pressing, and the dissolution could reach more than 95% in 30 min. The results of the orthogonal test showed that the dissolution effect of self-made tablets was faster than that of commercial products. [Conclusions] The glucosamine hydrochloride chondroitin sulfate tablets prepared by this prescription have better quality.

关 键 词：Glucosamine chondroitin sulfate tablets Optimization of formulation process Orthogonal test 

分 类 号：R95[医药卫生—药学]