心外膜脂肪组织分布和测量及与冠心病的联系  

Distribution and measurement of epicardial adipose tissue and its relationship with coronary heart disease

作　　者：公涵 孙欢[1] 吴晗[1] 于波[1] GONG Han;SUN Huan;WU Han;YU Bo(Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun,Jilin 130033,China)

机构地区：[1]吉林大学中日联谊医院心血管内科,吉林长春130033

出　　处：《中国临床研究》2023年第2期233-237,共5页Chinese Journal of Clinical Research

基　　金：吉林省科技厅项目(20200403091SF)。

摘　　要：心外膜脂肪组织(EAT)位于心肌与心包内脏层之间,与心肌及冠脉密切相关。生理状态下,EAT有着机械保护、产热、分泌及代谢等一系列功能,但在病理状态下,EAT可以激发炎症反应和氧化应激反应,分泌高水平的促炎及促氧化脂肪因子,最终成为血管疾病的促氧化剂及促炎介质的活性来源。这种改变与冠状动脉粥样硬化密切相关,近年来,随着EAT研究的不断深入,已经有大量文献证实EAT与疾病发展密切相关,包括冠心病、心力衰竭、心房颤动、高血压、糖尿病、非酒精性肝病、脑卒中等。本文将重点讨论EAT与冠心病之间的联系,通过EAT的生理特性及病理状态的改变,临床常见的影像测量方式,讨论EAT与冠心病之间的联系和EAT未来可能的治疗方向。Epicardial adipose tissue(EAT)is located between myocardium and pericardial visceral layer and is closely related to myocardium and coronary artery.In physiological state,EAT has a series of functions such as mechanical protection,heat production,secretion and metabolism.However,in pathological state,EAT can stimulate inflammatory response and oxidative stress response and secrete high levels of pro-inflammatory and pro-oxidative fat factors.Finally,it becomes the active source of pro-oxidants and pro-inflammatory mediators in vascular diseases.This change is closely related to coronary atherosclerosis.In recent years,with the deepening of EAT research,a large number of literatures have confirmed that EAT is closely related to the development of disease.Including coronary heart disease,heart failure,atrial fibrillation,hypertension,diabetes,non-alcoholic liver disease,stroke,etc.This article will focus on the relationship between EAT and coronary heart disease,through the physiological characteristics and pathological changes of EAT,the common clinical imaging measurement methods,discuss the relationship between EAT and coronary heart disease,and the possible treatment direction of EAT.

关 键 词：心外膜脂肪组织 冠状动脉粥样硬化 炎症反应 氧化应激 冠心病 

分 类 号：R543.3[医药卫生—心血管疾病]