重构本草——大黄  

Reconstruction of Chinese materia medica-rhubarb root and rhizome

作　　者：林潼 张湘苑 沈梦菲 张伟 赵林华[1] LIN Tong;ZHANG Xiangyuan;SHEN Mengfei;ZHANG Wei;ZHAO Linhua(Institute of Metabolie Discases,Guang anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinse Medicin,Beijing 10029,China;School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 73000,China)

机构地区：[1]中国中医科学院广安门医院代谢病研究所,北京100053 [2]北京中医药大学,北京100029 [3]甘肃中医药大学基础医学院,兰州730000

出　　处：《吉林中医药》2023年第2期215-217,共3页Jilin Journal of Chinese Medicine

基　　金：中国科学院学部咨询评议项目(2021-ZW10-A-017)。

摘　　要：通过对古籍文献调研、中药现代研究进展及其研究成果的梳理,结合中医临床及中药学等学科领域内的多位专家学者的认识及应用经验,经讨论认为大黄的功效主要为泻下攻积,清热泻火。症靶为便秘、热毒泻痢、湿热黄疸、痈肿疔疮。标靶为高血肌酐、高胆红素。现代药理研究发现大黄及其有效成分具有泻下、止血活血、调脂、利胆保肝、抗病原微生物、抗炎、免疫调节等作用。本品为峻烈攻下之品,易伤正气,如非实证,不宜妄用。临床使用剂量3~120 g,内服时当辨病辨证使用。Based on the investigation of ancient books and literature,the progress and achievements of modern research on traditional Chinese medicine,and the understanding and application experience of experts and scholars in the fields of clinical medicine and Chinese materia medica,it is believed that rhubarb root and rhizome has the following characteristics:Its effects are mainly relieving food retentions and clearing heat-fire,and its symptom targets are constipation,dysentery with the syndrome of heat-toxicity,jaundice with the syndrome of damp-heat and abscess,while its biochemical indicator targets are high serum creatinine and high bilirubin.The modern pharmacology discovers rhubarb root and rhizome and its effective components can play the roles of promoting purgation,stopping bleedings and activating the blood circulation,lowering blood lipids,dispersing stagnated liver qi for promoting bile flows,resisting pathogenic microorganisms,anti-inflammation,regulating immunity,etc.It is a drastic purgative that it should be taken with caution only for those with deficient syndromes.Its clinical dosage range is 3-120 g.When taken orally,it should be used according to different diseases or different stages of the same disease.

关 键 词：大黄 症靶 标靶 便秘 热毒泻痢 湿热黄疸 高血肌酐 高胆红素 临床回归 

分 类 号：R282.71[医药卫生—中药学]