血管生成与肺纤维化的发生发展  

Angiogenesis and pulmonary fibrosis

作　　者：吴妍 张军[2] 郑金旭[1] Wu Yan;Zhang Jun;Zheng Jinxu(Department of Respiratory and Critical Care Medicine,Affliated Hospital of Jiangsu University,Zhenjiang 212000,China;Department of Respiratory and Critical Care Medicine,Aoyang Hospital,Affiliated of Jiangsu University,Zhangjiagang 215600,China)

机构地区：[1]江苏大学附属医院呼吸与危重症医学科,镇江212000 [2]江苏大学附属澳洋医院呼吸与危重症医学科,张家港215600

出　　处：《中华结核和呼吸杂志》2023年第2期197-202,共6页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：镇江市重大(社会发展)项目(SH2018048);苏州市社会发展(民生医疗)项目(SYSD2020010)。

摘　　要：特发性肺纤维化是一种持续发展且不可逆性的肺间质疾病,以上皮细胞反复损伤,伴有纤维化性异常修复为特征,最终导致肺部结构错乱及蜂窝肺形成。其准确发病机制尚未完全阐明,而在众多机制中,血管生成也可能是促成IPF的始动因素之一。慢性进行性微血管重塑紊乱已被证实存在于IPF中,本文就血管生成的诱因、调节因子、调控机制、生成规律、治疗靶点等方面与肺纤维化发生发展关系作一阐述。Idiopathic pulmonary fibrosis(IPF)is a chronic,progressive and irreversible lung interstitial disease characterized by repeated damage and accompanied by fibrotic repair,which ultimately leads to structural disorder and destruction of lung tissue,resulting in honeycomb lung.The exact pathogenesis of IPF has not been fully elucidated,and among the many mechanisms,angiogenesis may also be one of the initiating factors of IPF.Chronic,progressive microvascular remodeling disorder has been proved to exist in IPF.This article reviewed the relationship between angiogenesis and development of pulmonary fibrosis in terms of inducement,regulatory factors,regulatory mechanisms,generate rules and therapeutic targets.

关 键 词：特发性肺纤维化 始动因素 肺间质疾病 血管生成 蜂窝肺 不可逆性 血管重塑 上皮细胞 

分 类 号：R563[医药卫生—呼吸系统]