基于数据挖掘《幼科杂病心法要诀》治疗小儿疳证用药规律  

Mining of rules of medication by Youke Zabing Xinfa Yaojue in the treatment of infantile malnutrition based on data

作　　者：张娜 王燕超 周海燕 郝佳 张焱 ZHANG Na;WANG Yanchao;ZHOU Haiyan;HAO Jia;ZHANG Yan(Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,China)

机构地区：[1]山西中医药大学,太原030024 [2]山西中医药大学儿科学教研室

出　　处：《中国中西医结合儿科学》2023年第1期61-66,共6页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：山西省中医药管理局科研课题(2019ZYYC013);山西中医药大学科技创新能力培育计划“基础研究专项”(2021PY-JC-20);2022年度山西省研究生教育教学改革课题(2022YJJG225)。

摘　　要：目的挖掘《幼科杂病心法要诀》中治疗小儿疳证的临床用药规律。方法从《幼科杂病心法要诀》提取治疗小儿疳证的方药信息,建立“《幼科杂病心法要诀》治疗小儿疳证用药的数据库”,同时采用频数统计、关联规则和聚类分析数据挖掘方法,对方药规律进行分析。结果共累计内服方剂46首,涉及中药124味,共计频次498次。甘草、黄连、茯苓、胡黄连等药物为常用药物。药物以补虚、清热药为主,药性寒、温居多,多归于脾胃二经。关联规则显示补虚药与补虚药、清热药与杀虫药、清热药与消食药之间存在较大的关联性。核心处方以肥儿丸进行加减,同时可分为3类处方。结论著作中治疗小儿疳证重视立足脾胃,用药寒温并用,攻补同行。Objective To explore the clinical medication rules by Youke Zabing Xinfa Yaojue in the treatment of children with infantile malnutrition.Methods Extract the medical records and prescriptions of infantile malnutrition from Youke Zabing Xinfa Yaojue,and establish the"Database of Youke Zabing Xinfa Yaojue medications for infantile malnutrition";meanwhile,the data mining methods(frequency statistics,association rules and cluster analysis)were used to analyze the clinical medication rules.Results A total of 46 prescriptions were selected,involving 124 kinds of Chinese medicines,with the frequency of application being 498.The commonly used hetbs included Licorice,Coptis chinensis,Poria cocos and Radix Picrorrhizae,etc.The herbs tonifying deficiency and antipyretic drugs accounted for the major part.The herbs with cold and warm nature accounted for a large proportion,mostly functioning through the spleen and stomach meridian.Association rules showed that there was close correlation between deficiency-nourishing drugs and deficiency-nourishing drugs,between heat-clearing drugs and anthelmintic drugs,as well as between heat-clearing drugs and digestant drugs.The core prescription was Fattening Baby Pill.It could be divided into three categories.Conclusion In the book,the treatment for infantile malnutrition should be based on the spleen and stomach,and the cold and warm drugs should be used at the same time,to attack the disease and tonify the body.

关 键 词：疳证 《幼科杂病心法要诀》 用药规律 儿童 

分 类 号：R272[医药卫生—中医儿科学]