稳态医学——维持机体健康和诊治疾病的新概念新策略  

Homeostatic medicine: new strategy and concept of health maintenance as well as diagnosis and treatment of diseases

作　　者：秦力铮[1] 周建 胡磊[1] 王松灵[1] Qin Lizheng;Zhou Jian;Hu Lei;Wang Songling(Beijing Laboratory of Oral Health,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学口腔健康北京实验室,北京100069

出　　处：《中华口腔医学杂志》2023年第2期109-117,共9页Chinese Journal of Stomatology

基　　金：口腔健康北京实验室专项资金(PXM2021_014226_000041);国家自然科学基金(82030031);中国医学科学院牙齿发育与再生创新单元(2019-I2M-5-031)。

摘　　要：稳态(homeostasis)是一种自我调节的动态平衡过程, 生物体系统通过这种过程保持系统稳定, 同时适应不断变化的外部条件, 从而维持正常的生命活动。稳态医学是研究生物体分子、细胞、器官及全身稳态平衡的科学, 是以维持稳态平衡为立足点继而维护人体健康、预防和诊疗疾病的综合性学科。稳态医学(homeostatic medicine)着眼于机体整体, 聚焦稳态在健康和疾病中的作用, 有望为维持健康和诊治疾病提供新的思路和策略。一氧化氮(nitric oxide, NO)在机体多系统稳态的调控中发挥重要作用, 硝酸盐可以通过硝酸盐-亚硝酸盐-NO途径调节机体NO发挥重要生理作用以维持机体稳态。存在于细胞膜及细胞内的硝酸盐转运通道唾液酸转运蛋白(sialin)可介导一系列细胞生物学功能, 其与硝酸盐产生的NO一起, 共同成为调控机体稳态的重要机制。Homeostasis is a dynamic balance process of self-regulating.Biological systems remain stable through adapting to changing external conditions to maintain normal life activities.Homeostatic medicine is the science of studying homeostasis of human molecules,cells,organs and the whole body.It is a comprehensive discipline based on maintaining homeostasis to keep human health and assist for diseases prevention and diagnoses.Homeostatic medicine focuses on the whole body and on the role of homeostasis in health and disease,which is expected to provide new ideas and strategies for maintaining health as well as diagnosing and treating diseases.Nitric oxide(NO)plays an important role in the control of multisystem homeostasis.Nitrate is an important substance in regulating NO homeostasis through the nitrate-nitrite-NO pathway.Sialin,nitrate transporter which is located in the cell membrane and cytoplasm,mediates multiple cellular biological functions.The nitrate-nitrite-NO pathway and sialin-mediated biological functions play an important role in the regulation of body homeostasis.

关 键 词：硝酸盐类 稳态 稳态医学 一氧化氮 唾液酸转运蛋白 

分 类 号：R33[医药卫生—人体生理学]