侵袭性肺部真菌感染的下呼吸道局部药物治疗  

Topical drug therapy of the lower respiratory tract for invasive pulmonary fungal infection

作　　者：王莉洁 牟向东 Wang Lijie;Mu Xiangdong(Department of Respiratory and Critical Care Medicine,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 100218,China)

机构地区：[1]清华大学附属、北京清华长庚医院呼吸与危重症医学科、清华大学临床医学院,北京100218

出　　处：《国际呼吸杂志》2023年第1期116-119,共4页International Journal of Respiration

基　　金：北京市属医院科研培育计划项目(PX2020041);清华大学春风基金国内科研专项(2020Z99CFY033)。

摘　　要：侵袭性肺部真菌感染需及时给予有效的抗真菌治疗,但常规抗真菌药物效果欠佳,且价格贵、疗程长、不良反应大、耐受性差。抗真菌药物的下呼吸道局部应用主要包括两种方式:经口鼻雾化吸入和经支气管镜局部灌注。下呼吸道局部应用抗真菌药物治疗肺真菌感染已显现出良好的临床疗效。本文将对侵袭性肺部真菌感染的下呼吸道局部药物治疗的现状及进展进行阐述。Invasive pulmonary fungal infection needs timely and effective antifungal treatment,but the conventional antifungal drugs show poor efficacy,high price,long treatment course,strong side effects,and weak tolerance.Topical application of antifungal drugs in the lower respiratory tract mainly includes two ways:inhalation through the mouth and nose and local bronchoscopic infusion.Antifungal topical therapy of the lower respiratory tract has shown good clinical efficacy in the treatment of pulmonary fungal infection.This article will review the current status and research progress of topical drug therapy for invasive pulmonary fungal infection in the lower respiratory tract.

关 键 词：肺疾病 真菌性 支气管肺泡灌洗 雾化吸入 

分 类 号：R519[医药卫生—内科学]