基于数据挖掘的中药专利复方治疗阿尔茨海默病用药规律  

Medication law of Traditional Chinese Medicine patent compounds in the treatment of Alzheimer disease based on data mining

作　　者：李珊珊[1] 赵敏[2] 孙江燕[2] 张杰[2] 闫园园 崔智慧 史梦龙 Li Shanshan;Zhao Min;Sun Jiangyan;Zhang Jie;Yan Yuanyuan;Cui Zhihui;Shi Menglong(Master Degree Student of Grade 2019,Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Encephalopathy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,郑州450046 [2]河南中医药大学第一附属医院脑病科,郑州450000

出　　处：《国际中医中药杂志》2023年第2期220-226,共7页International Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2017YFC1703502);河南省中医管理局河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才培养项目(CZ0133-48);河南省中医管理局河南省中医药科学研究专项基金(2019ZY2142)。

摘　　要：目的运用数据挖掘方法分析AD专利复方的用药规律。方法筛选专利数据库中治疗AD的中药复方,借助中医传承计算平台、SPSS Statistics 21.0及SPSS Modeler 18.0等软件进行频次统计、聚类分析和关联分析,分析用药规律。结果共纳入专利复方220个,涉及中药361味;排名前10的高频药依次为石菖蒲、远志、人参、川芎、黄芪、枸杞子、茯苓、熟地黄、当归、丹参;高频药中使用频次最高的药物类别为补虚药和活血化瘀药;药性多属温、平、寒;药味多属甘、苦、辛;归经多属五脏经络;关联规则分析得出关联数据16条,其中两项组合4条,三项组合12条,关联性最强的药组为“石菖蒲-远志”和“石菖蒲-川芎-远志”;聚类分析得出4个处方组合和3个药对组合,包含开心散、左归丸、八珍汤等加减结构。结论中药专利复方治疗AD以“调补五脏治其本,化痰祛瘀治其标”为核心治法,符合中医药治疗AD的理论基础,可为临床实践及新药研发提供参考。Objective To analyze the medication law of Traditional Chinese Medicine(TCM)patent compounds for Alzheimer disease(AD)by using data mining method.Methods The TCM compounds for the treatment of AD in the patent database were screened,and the frequency,clustering and association analysis were carried out with the help of TCM inheritance calculation platform,SPSS Statistics 21.0 and SPSS Modeler 18.0 software.The medication law was analyzed.Results A total of 220 patent compounds were included,involving 361 kinds of Chinese materia medica;the top 10 high-frequency drugs were Acori Tatarinowii Rhizoma,Polygalae Radix,Ginseng Radix et Rhizoma,Chuanxiong Rhizoma,Astragali Radix,Lycii Fructus,Poria,Rehmanniae Radix Praeparata Angelicae Sinensis Radix,Salviae Miltiorrhizae Radix et Rhizoma;the most frequently used drugs were drugs for tonifying deficiency and promoting blood circulation to remove blood stasis;most of their properties belonged to warm,mild and cold;the tastes were mainly sweet,bitter and pungent;the meridians belonged to the five internal organs.16 items of association data(4 combinations of two items and 12 combinations of three items)were obtained by association rule analysis,and the strongest correlation group was"Acori Tatarinowii Rhizoma-Polygalae Radix"and"Acori Tatarinowii Rhizoma-Chuanxiong Rhizoma-Polygalae Radix".Cluster analysis showed four prescription combinations and three pairs of drug compatibility,including the addition and subtraction structure of Kaixin Powder,Zuogui Pill,Bazhen decoction and so on.Conclusion The core treatment principle of TCM patent compound treatment of AD is regulating and tonifying the five internal organs to treat its root,resolving phlegm and removing blood stasis to treat the symptoms,which accords with the theoretical basis of TCM in the treatment of AD,and can provide reference for clinical practice and new drug research and development.

关 键 词：阿尔茨海默病 复方(中药) 数据挖掘 聚类分析 用药规律 

分 类 号：R277.7[医药卫生—中医学]