清利湿热法治疗慢性肾脏病理论内涵及研究进展  

Research progress in the theoretical connotation and mechanism of the eliminating dampness-heat method for the treatment of chronic kidney disease

作　　者：刘敏[1,2] 蒋春波[1,2] Liu Min;Jiang Chunbo(Master Degree Student of Grade 2020,Nanjing University of Chinese Medicine,Nanjing 210023,China;Department of Nephrology,Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215000,China)

机构地区：[1]南京中医药大学,南京210023 [2]南京中医药大学附属苏州市中医医院肾内科,苏州215000

出　　处：《国际中医中药杂志》2023年第1期113-116,共4页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82074368);江苏省高层次卫生人才“六个一工程”拔尖人才科研项目(LGY2020046);苏州市科技发展计划-医疗卫生科技创新关键技术项目(SKY2021058);苏州市第五批姑苏卫生拔尖人才项目(GSWS2019063)。

摘　　要：探讨清利湿热法治疗慢性肾脏病(CKD)的理论内涵及机制,为清利湿热法治疗CKD提供理论支撑,进一步阐释“湿热伤肾”的现代科学内涵。中医认为,湿热是造成肾脏损害的重要病机,清利湿热法在抑制CKD免疫炎症反应、改善氧化应激状态、拮抗肾脏纤维化方面起关键作用,机制主要与调控TNF-α水平、阻断NF-κB信号通路、抑制炎症因子、拮抗TGF-β1分泌等多种途径相关。This article aimed to explore the theoretical connotation and mechanism of clearing damp-heat method in the treatment of chronic kidney disease(CKD),provide theoretical support for clearing damp-heat method in the treatment of chronic kidney disease,and further explain the modern scientific connotation of"damp-heat impairing kidney".Modern Traditional Chinese Medicine(TCM)believes that damp-heat is an important pathogenesis of kidney damage.Clearing damp-heat method plays a key role in inhibiting CKD immune inflammatory response,improving oxidative stress and antagonizing renal fibrosis.The mechanism is mainly related to the regulation of TNF-αlevel,blocking NF-κB signaling pathway,inhibiting inflammatory cytokines,antagonizing TGF-β1 secretion and other pathways.

关 键 词：中医药治法 清利湿热法 慢性肾脏病 免疫炎症 氧化应激 肾脏纤维化 

分 类 号：R277.5[医药卫生—中医学]