鼠疫减毒活疫苗研究现状与展望  

Live-attenuated Yersinia pestis vaccines

作　　者：郭晓 仝泽辉 杜宗敏 GUO Xiao;TONG Zehui;DU Zongmin(State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China;School of Basic Medical Science,Anhui Medical University,Hefei 230032,Anhui,China)

机构地区：[1]军事科学院军事医学研究院微生物流行病研究所、病原微生物生物安全国家重点实验室,北京100071 [2]安徽医科大学基础医学院,安徽合肥230032

出　　处：《微生物学报》2023年第2期567-581,共15页Acta Microbiologica Sinica

基　　金：病原微生物生物安全国家重点实验室开放课题(SKLPBS2135)。

摘　　要：鼠疫(plague)是由鼠疫耶尔森氏菌(Yersinia pesits)引起的烈性传染病,在人类历史上曾造成约2亿人的死亡,在我国被列为甲类传染病。由于鼠疫菌具有高度致病性、传染性,被列为最具潜力的生物战剂和生物恐怖剂。在面临鼠疫威胁时,疫苗是最为有力的武器。鼠疫疫苗研究中,减毒活疫苗是重要的研究方向,现就鼠疫减毒活疫苗的研究现状进行综述,为新疫苗的研制提供参考。Plague caused by Yersinia pestis is a fulminating infectious disease,resulting in nearly 200 million deaths in human history.It is listed as a category A infectious disease in China.As a highly infectious pathogen,Y.pestis is considered one of the most potential biological weapons and biothreat agents.Prophylactic vaccination is a powerful measure for counteracting this disease.In the development of plague vaccines,live-attenuated vaccine is an important research direction.This review introduces the recent progress,current challenges,as well as the future prospects on the development of live-attenuated plague vaccines.

关 键 词：鼠疫 鼠疫耶尔森氏菌 减毒活疫苗 

分 类 号：R392-33[医药卫生—免疫学]