中西医结合治疗复治肺结核的疗效评价  

Evaluation of the curative effect of the combination of traditional Chinese and Western medicine on retreated pulmonary tuberculosis

作　　者：张燕 仵倩红 王帆 景凤英 邱峥 马喜迎 邵小霞 南亚 徐红艳 ZHANG Yan;WU Qianhong;WANG Fan;JING Fengying;QIU Zheng;MA Xiying;SHAO Xiaoxia;NAN Ya;XU Hongyan(Department of Integrated Traditional Chinese and Western Medicine,Tuberculosis Prevention and Treatment Hospital of Shaanxi Province,Xi'an,Shaanxi 710105,China;Department of Internal Medi-cine,Tuberculosis Prevention and Treatment Hospital of Shaanxi Province,Xi'an,Shaanxi 710105,China)

机构地区：[1]陕西省结核病防治院中西医结合科,陕西西安710105 [2]陕西省结核病防治院结核内六科,陕西西安710105

出　　处：《安徽医药》2023年第3期615-619,共5页Anhui Medical and Pharmaceutical Journal

基　　金：陕西省中医药管理局资助项目(2021-ZZ-LC028)。

摘　　要：目的 探究中西医结合治疗对复治肺结核病人的治疗效果及生活质量的影响。方法 选取2019年1月至2021年1月间在陕西省结核病防治院进行治疗的复治肺结核病人70例,采用随机数字表法将其分为两组,每组各35例。对照组采用西医化疗法治疗,研究组采用中医抗痨丸结合西医化疗法治疗,对两组病人的临床疗效、中医症状积分、T淋巴细胞亚群、肺功能、生活质量进行比较分析。结果 治疗后,两组中医症状积分和CD8+水平下降,CD3+、CD4+、CD4+/CD8+水平上升,且研究组中医症状积分和CD8+水平显著低于对照组,CD3+、CD4+、CD4+/CD8+水平显著高于对照组(P<0.05)。研究组显效28例、有效5例、无效2例,对照组显效19例、有效8例、无效8例,研究组疗效显著优于对照组(P<0.05)。治疗后,两组第一秒用力呼气容积/用力肺活量(FEV1/FVC)及呼气流速峰值(PEFR)参数、WHO生存质量测定量表简表(WHOQOL-BREF)各维度评分均上升,且研究组FEV1/FVC参数(83.47±9.27)%显著高于对照组(77.65±8.63)%,PEFR参数(5.62±1.12)L/s显著高于对照组(4.73±0.95)L/s,WHOQOL-BREF各维度评分显著高于对照组(P<0.05)。结论 中西医结合治疗复治肺结核病人能显著提升病人疗效,改善病人中医症状及免疫功能,提升病人肺功能、生活质量。Objective To explore the effects of integrated traditional Chinese and Western medicine treatment on the therapeutic effect and quality of life of retreated pulmonary tuberculosis patients.Methods Seventy patients with retreated pulmonary tuberculosis who were treated in Shaanxi Tuberculosis Control and Prevention Hospital between January 2019 and January 2021 were selected and divided into two groups by using the random number table method, with 35 cases in each group. Western medicine chemotherapy was adopted for the control group, and the Chinese medicine Kanglao pill combined with Western medicine chemotherapy was adopted for the study group. The clinical efficacy, TCM symptom scores, T-lymphocyte subsets, lung function, and quality of life of the two groups of patients were compared and analyzed.Results After treatment, the TCM symptom score and CD8+ level decreased, and the CD3+,CD4+, and CD4+/CD8+ levels increased in both groups. The TCM symptom score and CD8+ level were significantly lower and the CD3+, CD4+, and CD4+/CD8+ levels were significantly higher in the study group than in the control group(P < 0.05). In the study group, 28 cases were significantly effective, 5 cases were effective, and 2 cases were ineffective. In the control group, 19 cases were significantly effective, 8 cases were effective, and 8 cases were ineffective. The curative effect of the study group was significantly better than that of the control group(P < 0.05). After treatment, the first second forced expiratory volume/forced vital capacity(FEV1/FVC),peak expiratory flow rate(PEFR) parameters and quality of life scale(WHOQOL-BREF) scores increased in both groups, and the FEV1/FVC parameters in the study group(83.47±9.27)% were significantly higher than those in the control group(77.65±8.63)%, and the PEFR parameters(5.62±1.12) L/s were significantly higher than those in the control group(4.73±0.95) L/s, and the WHOQOL-BREF scores were significantly higher than those in the control group(P < 0.05).Conclusion Integrated tradit

关 键 词：结核 肺 抗结核药 医学 中国传统 药物疗法 联合 抗痨丸 T淋巴细胞亚群 生活质量 

分 类 号：R521[医药卫生—内科学]