化痰通腑汤加减治疗中风急性期患者的临床效果  

Clinical Efficacy of Huatan Tongfu Decoction Addition and Subtraction in the Treatment of Acute Stage of Patients with Stroke

作　　者：王文学 WANG Wenxue(Zaoyang Hospital of Traditional Chinese Medicine,Zaoyang 441200,China)

机构地区：[1]枣阳市中医医院,湖北枣阳441200

出　　处：《中外医学研究》2023年第4期35-39,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察化痰通腑汤加减在中风急性期患者中的应用效果。方法:选取2019年2月—2021年2月枣阳市中医医院内二科96例中风急性期患者作为研究样本。根据随机数表法将其分为对照组和观察组,各48例。两组均给予西医综合性治疗,观察组在此基础上给予化痰通腑汤加减治疗。比较两组临床疗效,治疗前后中医症候积分、相关指标、日常活动能力、生活质量及不良反应。结果:观察组总有效率高于对照组(P<0.05)。治疗后,观察组恶心呕吐、言语不利、头晕头痛、口角歪斜、肢体偏瘫、意识障碍评分均低于对照组(P<0.05)。治疗后,观察组中枢神经特异性蛋白(S100-β)、神经元特异性烯醇化酶(NSE)、血栓素B2(TXB2)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平均低于对照组,一氧化氮(NO)、6-酮-前列腺素F1α(6-keto-PGF1α)水平均高于对照组(P<0.05)。治疗后,观察组日常活动能力评定量表(ADL)及生活质量评定量表(SF-36)评分均高于对照组(P<0.05)。两组均未出现严重的不良反应。结论:对中风急性期患者提供化痰通腑汤加减治疗,可显著提高其临床治疗有效率,改善临床症状、神经功能、血管内皮功能损伤程度,有助于提升预后质量,值得推广。Objective:To observe the application effect of Huatan Tongfu Decoction Addition and Subtraction in the acute stage of patients with stroke.Method:A total of 96 patients with acute stage of stroke in the Second Department of Internal Medicine of Zaoyang Hospital of Traditional Chinese Medicine from February 2019 to February 2021 were selected as study samples.They were divided into control group and observation group according to random number table method,48 cases in each group.Both groups were given western medicine comprehensive treatment,and the observation group was given Huatan Tongfu Decoction Addition and Subtraction treatment on this basis.The clinical efficacy,traditional Chinese medicine symptom scores,related indexes,ability of daily activities,quality of life before and after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was higher than that of control group (P<0.05).After treatment,nausea and vomiting,speech impairment,dizziness and headache,lopsided mouth,limbs hemiplegia and consciousness disorder scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of central nerve specific protein (S100-β),neuron specific enolase (NSE),thromboxane B2(TXB2),C-reactive protein (CRP),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the observation group were lower than those in the control group,the levels of nitric oxide (NO) and 6-keto-prostaglandin F1α (6-keto-PGF1α) were higher than those of control group (P<0.05).After treatment,the scores of ability of daily activities scale (ADL) and quality of life scale (SF-36) in observation group were higher than those in control group (P<0.05).There were no serious adverse reactions in both groups.Conclusion:The treatment of Huatan Tongfu Decoction Addition and Subtraction in acute stage of stroke patients can significantly improve the effective rate of clinical treatment,improve clinical symptoms,neurological function,v

关 键 词：化痰通腑汤 中风 急性期 临床症状 

分 类 号：R255.2[医药卫生—中医内科学]