异甘草酸镁辅助治疗重度慢性乙型肝炎患者的效果  

Effect of Magnesium Isoglycyrrhizinate in the Adjuvant Treatment of Patients with Severe Chronic Hepatitis B

作　　者：濮阳娟 吴卫华 张胥磊 费勇 PU Yangjuan;WU Weihua;ZHANG Xulei;FEI Yong(Nanjing Gaochun People's Hospital,Nanjing 211300,China;不详)

机构地区：[1]南京市高淳人民医院,江苏南京211300 [2]南京大学医学院附属鼓楼医院

出　　处：《中外医学研究》2023年第5期134-137,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究异甘草酸镁辅助治疗重度慢性乙型肝炎患者的效果及对相关细胞因子水平变化的影响。方法:选取2019年11月—2021年3月于南京市高淳人民医院就诊并确诊为重度慢性乙型肝炎的99例患者,根据随机数表法将其分为观察组(n=50)与对照组(n=49)。对照组给予常规抗病毒及护肝治疗,观察组在对照组的基础上给予异甘草酸镁治疗。比较两组治疗后的临床效果、肝功能、血生化指标。结果:治疗后,观察组总有效率(84.00%)明显高于对照组(65.31%)(P<0.05)。治疗前,两组门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)及总胆红素(TBIL)比较,差异无统计学意义(P>0.05);治疗后,两组的AST、ALT、TBIL均低于治疗前,且观察组低于对照组(P<0.05)。治疗前,两组外周血调节性T细胞(Treg)及辅助性T细胞17(Th17)占比、白细胞介素-1(IL-1)、白细胞介素-4(IL-4)及肿瘤坏死因子-α(TNF-α)的水平比较,差异无统计学意义(P>0.05);治疗后,两组Treg、Th17、IL-1、IL-4及TNF-α均低于治疗前,且观察组低于对照组(P<0.05)。结论:异甘草酸镁辅助治疗重度慢性乙型肝炎效果良好,可有效改善肝功能和提高机体免疫功能,减轻炎症反应。Objective: To explore the effect of Magnesium Isoglycyrrhizinate in the adjuvant treatment of patients with severe chronic hepatitis B and its influence on the changes of related cytokines. Method: A total of 99 patients with severe chronic hepatitis B diagnosed in Nanjing Gaochun People’s Hospital from November 2019 to March 2021 were selected. They were divided into observation group(n=50) and control group(n=49) according to random number method. The control group was given routine antiviral and liver protection treatment, while the observation group was given Magnesium Isoglycyrrhizinate treatment on the basis of the control group. The clinical effect, liver function and blood biochemical indexes of the two groups were compared after treatment. Result: After treatment,the total effective rate of the observation group(84.00%) was significantly higher than that of the control group(65.31%)(P<0.05). Before treatment, there were no significant differences between the two groups in aspartate aminotransferase(AST), alanine aminotransferase(ALT)and total bilirubin(TBIL)(P>0.05). After treatment, the AST, ALT and TBIL of the two groups were lower than those before treatment, and the observation group were lower than those in the control group(P<0.05). Before treatment, there were no significant differences between the two groups in the proportion of peripheral blood regulatory T cells(Treg) and helper T cells 17(Th17), interleukin-1(IL-1),interleukin-4(IL-4) and tumor necrosis factor-α(TNF-α)(P>0.05). After treatment, Treg, Th17, IL-1, IL-4 and TNF-α in both groups were lower than those before treatment, and the observation group were lower than those in the control group(P<0.05).Conclusion: Magnesium Isoglycyrrhizinate has a good effect in the adjuvant treatment of severe chronic hepatitis B, which can effectively improve liver function, improve immune function and reduce inflammatory reaction.

关 键 词：异甘草酸镁 重度慢性乙型肝炎 T淋巴细胞 免疫炎症 

分 类 号：R512.62[医药卫生—内科学]