纳米递药系统在膀胱功能障碍性疾病及膀胱肿瘤治疗中的研究进展  

Progress of Nano-drug Delivery Systems in Treatment of Bladder Dysfunction Diseases and Bladder Tumors

作　　者：赵颖[1,2] 许克新[3] 胡浩[3] 王慧梅[1] 王连艳[2,4] ZHAO Ying;XU Kexin;HU Hao;WANG Huimei;WANG Lianyan(Heilongjiang Key Lab.of Ecological Utilization of Forest Derived Active Substances,Key Lab.of Forest Plant Ecology,Ministry of Education,College of Chemistry,Chemical Engineering and Resource Utilization,Northeast Forestry University,Harbin 150040;Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190;Dept.of Urology,Peking University People’s Hospital,Beijing 100044;College of Chemical Engineering,University of Chinese Academy of Sciences,Beijing 100049)

机构地区：[1]东北林业大学化学化工与资源利用学院,森林植物生态学教育部重点实验室,黑龙江省林源活性物质生态利用重点实验室,黑龙江哈尔滨150040 [2]中国科学院过程与工程研究所,北京100190 [3]北京大学人民医院泌尿外科,北京100044 [4]中国科学院大学化工学院,北京100049

出　　处：《中国医药工业杂志》2022年第12期1706-1714,共9页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金资助项目(81970660、81973262)。

摘　　要：在膀胱功能障碍性疾病及膀胱肿瘤治疗中,纳米技术作为一项新兴的治疗策略,因其有效的尺寸效应、可靶向修饰等优势,为药物体内高效递送提供了广阔的应用前景。作为治疗膀胱疾病的有效给药途径,膀胱内灌注的疗效优于全身给药途径。然而,周期性排尿会冲洗掉灌注入的药物,导致药物的持续作用时间减少;膀胱通透性屏障的存在也限制了药物向炎症部位及肿瘤组织的渗透。因此,开发新型纳米给药系统至关重要。该研究综述了纳米递药系统治疗膀胱功能障碍性疾病和膀胱肿瘤的相关研究,以期为今后改进临床治疗手段提供更多的思路和方法。In the treatment of bladder dysfunctional diseases and bladder tumors,as an emerging therapeutic strategy,nanotechnology provides promising applications for efficient drug delivery in vivo due to its effective size effect and targeting modifications.As an effective administration route for the treatment of bladder diseases,intravesical instillation shows superior efficacy compared with systemic administration.However,periodic urination flushes out the instilled drug,resulting in a reduced duration of action.In addition,the existence of a bladder permeability barrier limits drug penetration into the inflammatory sites and tumor tissues.Therefore,it is crucial to develop a novel nanodrug delivery system.This study reviews researches related to nano-drug delivery systems for the treatment of bladder dysfunctional diseases and bladder tumors,with the aim of providing more ideas and methods for improvement of clinical treatments in the future.

关 键 词：纳米递药体系 膀胱功能障碍 膀胱肿瘤 膀胱灌注 

分 类 号：R944.9[医药卫生—药剂学]