酸枣仁皂苷A的药理作用研究进展  

Research progress of pharmacological actions of jujuboside A

作　　者：杨丽萍 黄嘉禧 邓丽娟 YANG Liping;HUANG Jiaxi;DENG Lijuan(Formula-Pattern of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Jinan University,Guangzhou 510630,Guangdong,China)

机构地区：[1]暨南大学中医学院方证研究中心,广东广州510632

出　　处：《上海中医药大学学报》2023年第1期90-97,共8页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81803790);广东省自然科学基金资助项目(2020A1515011090);广东省中医药管理局项目(20200511205949)。

摘　　要：酸枣仁皂苷A(JuA)是酸枣仁中皂苷的主要成分。国内外研究表明JuA具有镇静安神、改善睡眠、神经保护、改善记忆、心脏保护、抗氧化、抗炎及抗肿瘤等广泛的药理效应。随着药理学研究方法和技术的更新,JuA的药代动力学、药理作用及相关分子机制不断被发现和深入研究。因此,本文对JuA的药代动力学和药理作用的研究进展作一阐述,并为以后的研究提供参考。Jujuboside A(JuA) is the main component of saponin in Ziziphi Spinosae Semen. Domestic and foreign studies have shown that JuA has a wide range of pharmacological effects, such as sedation, sleep improvement, neuroprotection, memory improvement, heart protection, anti-oxidation, anti-inflammation, and anti-tumor. With the update of pharmacological research methods and techniques, the pharmacokinetics, pharmacological effects and related molecular mechanisms of JuA have been continuously discovered and further investigated. In this paper, the research progress of pharmacokinetics and pharmacological actions of JuA was elaborated, which can provide references for future researches.

关 键 词：酸枣仁皂苷A 药代动力学 药理活性 分子机制 

分 类 号：R285[医药卫生—中药学]