铁死亡在主动脉夹层中的研究进展  

Research progress of ferroptosis in aortic dissection

作　　者：吴瑶瑶 李娜[1] 孙明慧 王秉翔 张志勉[1] Wu Yaoyao;Li Na;Sun Minghui;Wang Bingxiang;Zhang Zhimian(Department of Health Management Center,Qilu Hospital of Shandong University,Ji'nan 250012,China;Department of spine surgery,Shandong Provincial Hospital,Ji'nan 250021,China)

机构地区：[1]山东大学齐鲁医院健康管理中心,济南250012 [2]山东省立医院脊柱外科,济南250021

出　　处：《中华老年医学杂志》2023年第2期229-233,共5页Chinese Journal of Geriatrics

基　　金：山东省重大科技创新工程项目(2019JZZY011110)。

摘　　要：主动脉夹层,尤其Stanford A型主动脉夹层,是一种急性进展、高致死性的严重心血管疾病,早期预防和及时治疗可减少死亡率,减轻家庭和社会负担。然而因其病因机制目前尚不清楚,临床治疗仍以手术为主,早期预防和药物应用非常局限。最近的一些研究结果显示,铁死亡在主动脉夹层的发生、发展中可能发挥重要作用,对两者关系的揭示或可为该病的预防、治疗及临床研究提供思路。Aortic dissection,especially Stanford type A aortic dissection,is an acutely progressive and highly fatal cardiovascular disease.Early prevention and timely treatment can greatly reduce mortality and reduce the burden on families and society.However,due to the etiological mechanism is still unclear,the clinical treatment is still mainly surgery,and the early prevention and drug application are very limited.And some recent studies have found that ferroptosis may play an important role in the occurrence and development of aortic dissection,revealing the relationship between them may provide ideas for the prevention,treatment and scientific research of the disease.

关 键 词：肌细胞 平滑肌 内皮细胞 细胞外基质 铁死亡 主动脉夹层 

分 类 号：R543.1[医药卫生—心血管疾病]