急性肾损伤转化为慢性肾脏病的机制  

Mechanisms of the acute kidney injury to chronic kidney disease transition

作　　者：张辉[1] 潘斌斌[1] 万辛[1] Zhang Hui;Pan Binbin;Wan Xin(Department of Nephrology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)肾内科,南京210006

出　　处：《中华老年医学杂志》2023年第2期234-238,共5页Chinese Journal of Geriatrics

基　　金：江苏省2020年高层次卫生人才"六个一工程"拔尖人才项目(LGY2020014)。

摘　　要：急性肾损伤(AKI)是临床常见的病理生理现象,其具有高发病率、高ICU住院率及高死亡率等特点;此外,AKI也是慢性肾脏病(CKD)及终末期肾病的独立危险因素。目前多项研究已揭示了AKI向CKD的转化方面所涉及的多种机制,但是有效的预防及治疗手段仍无突破性进展。本文就AKI向CKD转化的机制作一综述,以期为进一步的干预提供潜在的靶点。Acute kidney injury(AKI)is a common clinical pathophysiological phenomenon,which is characterized by high morbidity,ICU hospitalization rate and mortality.In addition,AKI is an independent risk factor for chronic kidney disease(CKD)and end-stage renal disease.A number of studies have revealed various mechanisms involved in the transition of AKI to CKD,but there is still no breakthrough in effective prevention and treatment.This article reviews the mechanisms of transition from AKI to CKD,and expects to provide potential targets for further intervention.

关 键 词：急性肾损伤 慢性肾脏病 机制 病理生理 

分 类 号：R692[医药卫生—泌尿科学]