2型糖尿病患者四肢骨骼肌量与踝肱指数的相关性  

Association between appendicular skeletal muscle mass and ankle-brachial index in patients with type 2 diabetes

作　　者：韩青[1] 刘莉莉[1] 潘烨 杨兵全[1] 徐娟[1] 何花[1] 孙子林[1] 邱山虎[3] Qing Han;Lili Liu;Ye Pan;Bingquan Yang;Juan Xu;Hua He;Zilin Sun;Shanhu Qiu(Department of Endocrinology,Zhongda Hospital,Southeast University,Nanjing 210009,China;School of Medicine,Southeast University,Nanjing 210009,China;Department of General Practice,Zhongda Hospital,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院内分泌科,南京210009 [2]东南大学医学院,南京210009 [3]东南大学附属中大医院全科,南京210009

出　　处：《中华健康管理学杂志》2023年第1期36-40,共5页Chinese Journal of Health Management

基　　金：江苏省老年健康科研项目资助项目(LKM2022027);江苏省重点研发计划(BE2022828)。

摘　　要：目的探讨2型糖尿病患者四肢骨骼肌量(ASM)与踝肱指数(ABI)的相关性。方法本研究为横断面研究,选取2018年7月—2019年3月东南大学附属中大医院内分泌科的2型糖尿病患者278例(男/女:158/120例),收集患者一般资料、临床生化指标、ABI,应用体质成分分析仪测定肌肉量,获取ASM,并计算四肢骨骼肌指数(ASMI)、四肢骨骼肌体重比(SMI)及四肢骨骼肌体重指数比(ASM/BMI)。利用相关性分析及多重线性回归分析不同方法校正后的上述指标与ABI之间的相关性。结果Pearson相关分析发现在所有患者中,ABI与ASM(r=0.14,P=0.020)、ASMI(r=0.13,P=0.030)、ASM/BMI(r=0.13,P=0.030)呈正相关,而与SMI(r=0.12,P=0.053)无相关性。多元逐步回归分析显示:在校正相关混杂因素后,ASMI(β=0.053,95%CI:0.006~0.101,P=0.027)、ASM/BMI(β=0.347,95%CI:0.040~0.654,P=0.027)均与ABI比较差异有统计学意义。结论2型糖尿病患者ASM与ABI之间存在显著相关性。Objective To assess the relationship between appendicular skeletal muscle mass(ASM)and ankle brachial index(ABI)among patients with type 2 diabetes.Methods In this cross-sectional study,from July 2018 to March 2019,a total of 278 patients with type 2 diabetes treated in Zhongda Hospital were enrolled in this study,and there were 158 males and 120 females.General information and clinical biochemical parameters and ABI in the patients were collected.The appendicular muscle mass was quantitatively measured with body composition analyzer to achieve ASM.And the appendicular skeletal muscle mass index(ASMI),skeletal muscle index(SMI),and appendicular skeletal muscle mass/body mass index(ASM/BMI)were calculated respectively.Correlation analysis and multiple linear regression analyses with different adjustment models were conducted to analyze the correlation between ABI and above-mentioned indexes.Results The Pearson correlation analysis showed that ABI had significant positive correlation with ASM,ASMI and ASM/BMI(r=0.14,0.13,0.13,all P<0.05),but a marginal relation with SMI(r=0.116,P=0.053).Multiple linear regression analysis suggested that ASMI(β=0.053,95%CI:0.006-0.101,P=0.027)and AMI/ABI(β=0.347,95%CI:0.040-0.654,P=0.027)were significantly related to ABI.Conclusion ASM is positively associated with ABI in patients with type 2 diabetes.

关 键 词：糖尿病 2型 四肢骨骼肌量 踝肱指数 

分 类 号：R587.1[医药卫生—内分泌]