河北省成年居民血脂异常与糖尿病家族史对糖尿病患病的交互作用  

Interaction of dyslipidemia and family history of diabetes on diabetes among the adults in Hebei Province

作　　者：曹亚景[1] 唐丽娟[1] 赵晶晶 李玫 张帆[1] 岳福娟 蒋东升[1] Yajing Cao;Lijuan Tang;Jingjing Zhao;Mei Li;Fan Zhang;Fujuan Yue;Dongsheng Jiang(Institute of Prevention and Control of Non-communicable Chronic Diseases,Hebei Province Center for Disease Prevention and Control,Shijiazhuang 050021,China)

机构地区：[1]河北省疾病预防控制中心慢性非传染性疾病防治所,石家庄050021

出　　处：《中华糖尿病杂志》2023年第1期39-46,共8页CHINESE JOURNAL OF DIABETES MELLITUS

基　　金：河北省医学科学研究课题计划(20220790)。

摘　　要：目的探讨河北省成年居民血脂异常与糖尿病家族史对糖尿病患病的交互作用。方法为横断面研究。2018年10—12月利用中国慢性病及其危险因素监测的数据,采用多阶段整群分层随机抽样的方法抽取河北省成年常住人口为研究对象。收集研究对象血糖、血脂。采用复杂加权估算研究对象糖尿病患病率。使用相加模型分析河北省成年居民血脂异常与糖尿病家族史对糖尿病患病的交互作用。计算交互作用的相对超额危险度(RERI)、交互作用归因比(AP)、交互作用指数(SI),以评估加法量表上的相互作用效应。结果共纳入7725例研究对象,糖尿病加权患病率为13.1%。相加模型分析结果显示,血脂异常且有糖尿病家族史者患糖尿病的风险是血脂正常且无糖尿病家族史者的5.407倍(95%CI 4.306~6.790,P<0.001),RERI、AP和SI分别为1.224(95%CI 0.015~2.433)、0.226(95%CI 0.035~0.417)和1.384(1.012~1.894)。高密度脂蛋白胆固醇异常且有糖尿病家族史者患糖尿病的风险是高密度脂蛋白胆固醇正常且无糖尿病家族史者的5.398倍(95%CI 3.995~7.294,P<0.001),RERI、AP和SI分别为2.203(95%CI 0.710~3.696)、0.408(95%CI 0.231~0.585)、2.004(95%CI 1.361~2.951)。结论血脂异常和糖尿病家族史的暴露可能对糖尿病患病产生相加交互作用。Objective To investigate the interaction between dyslipidemia and family history of diabetes mellitus on the risk of diabetes mellitus among adults in Hebei Province.Methods This study was a cross-sectional study.Using data from the China Chronic Disease and Risk Factor Surveillance(CCDRFS),residents aged≥18 years were selected through multistage clustering sampling from October to December 2018.The data of individual′s blood glucose and lipid were collected.Complex weighting was used to estimate the prevalence of diabetes in the subjects.The additive model was used to analyze the interaction between dyslipidemia and family history of diabetes mellitus in adult residents of Hebei Province.The relative excess risk of interaction(RERI),the attributable proportion of interaction(AP),and the synergy index(SI)were calculated to assess the interaction effect on the additive scale.Results A total of 7725 subjects aged≥18 years were finally included in this study,and the prevalence of diabetes mellitus was 13.1%.The results of the model analysis showed that the risk of dyslipidemia residents who had family history of diabetes mellitus was of 5.407 times higher(95%CI 4.306-6.790,P<0.001)than those in the normal group with RERI,AP and SI of 1.224(95%CI 0.015-2.433),0.226(95%CI 0.035-0.417)and 1.384(95%CI 1.012-1.894),respectively.The residents with high-density lipoprotein cholesterol(HDL-C)and family history of diabetes mellitus group had a 5.398 times greater risk of developing diabetes than those with the normal group(95%CI 3.995-7.294,P<0.001)with RERI,AP and SI of 2.203(95%CI 0.710-3.696),0.408(95%CI 0.231-0.585)and 2.004(95%CI 1.361-2.951),respectively.Conclusion The exposures of both dyslipidemia and family history of diabetes mellitus could result in an additive interaction effect on diabetes mellitus.

关 键 词：糖尿病 血脂异常 糖尿病家族史 交互作用 

分 类 号：R587.1[医药卫生—内分泌]