Synthesis of pyrimidines from dinitrogen and carbon  

作　　者：Xianghui Shi Qianru Wang Chao Qin Li-Jun Wu Yuanjin Chen Gao-Xiang Wang Yongli Cai Wenbo Gao Teng He Junnian Wei Jianping Guo Ping Chen Zhenfeng Xi 

机构地区：[1]Beijing National Laboratory for Molecular Sciences(BNLMS),Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,College of Chemistry,Peking University,Beijing 100871,China [2]Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]State Key Laboratory of Catalysis,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023.China

出　　处：《National Science Review》2022年第12期214-220,共7页国家科学评论（英文版）

基　　金：supported by the Basic Science Center of Transformation Chemistry of Key Components of Air;the National Natural Science Foundation of China(21988101).

摘　　要：The element nitrogen and nitrogenous compounds are vital to life.The synthesis of nitrogen-containing compounds using dinitrogen as the nitrogen source,not through ammonia,is of great interest and great value but remains a grand challenge.Herein,we describe a strategy to realize this transformation by combining the heterogeneous approach with the homogeneous methodology.The N_(2)molecule was first fixed with carbon and LiH through a one-pot heterogeneous process,forming Li_(2)CN_(2)as an’activated’nitrogen source with high efficiency.Then subsequent homogeneous treatments of Li_(2)CN_(2)to construct the organic synthon carbodiimide and the RNA/DNA building block pyrimidines were fulfilled.By using^(15)N_(2)as the feedstock,their corresponding^(15)N-labeled carbodiimide and pyrimidines were readily obtained.This homogeneous-heterogeneous synergy strategy will open a new chapter for N_(2)transformation.

关 键 词：dinitrogen transformation nitrogen fixation N-C bond formation homogeneous-heterogeneous synergy strategy 15n-labeled pyrimidines 

分 类 号：O626[理学—有机化学]