外泌体在增生性瘢痕和瘢痕疙瘩治疗中的研究进展  

The research progress of exosome in the treatment of hypertrophic scar and keloid

作　　者：陶瑞 谭植襄 李思成 张伟[2] 阮晶晶[2] 余墨声[1] 朱占永[1] TAO Rui;TAN Zhixiang;LI Sicheng(Department of Plastic and Aesthetic Surgery,Wuhan University People's Hospital,Wuhan 430060,China;不详)

机构地区：[1]武汉大学人民医院整形美容外科,430060 [2]武汉大学附属同仁医院暨武汉市第三医院烧伤科

出　　处：《临床外科杂志》2022年第12期1196-1199,共4页Journal of Clinical Surgery

基　　金：湖北省卫生健康科研基金(WJ2021F106)。

摘　　要：在人体创伤修复过程的终末阶段,常会伴随瘢痕的产生。当机体有序的修复过程被打破,创面异常愈合,便可能产生增生性瘢痕、瘢痕疙瘩,给病人带来身心负担的同时,也会造成大量医疗资源的消耗。临床上瘢痕主要通过外科手术、局部放射、药物注射等方式治疗,但其疗效与预期仍存在差距,探求新的治疗方案具有重要意义。有研究表明,外泌体对瘢痕有一定治疗作用。本综述将总结外泌体用于增生性瘢痕和瘢痕疙瘩治疗的作用机制及研究进展。In the terminal stage of the human wound repair process,it is often accompanied by scar formation.Hypertrophic scar and keloid may occur when the orderly repair process of the body is broken and the wound heals abnormally.The emergence of them not only brings physical and mental burden to patients,but also consumes a lot of medical resources.Clinically,scar is mainly treated by surgery,local radiation and drug injection,but there is still a little gap between its curative effect and expectation.Therefore,it is of great significance to explore new treatment methods.Existing studies have shown that exosomes have a certain therapeutic effect on scar.This review will summarize the mechanism and recent research progress of exosome in the treatment of hypertrophic scar and keloid.

关 键 词：外泌体 增生性瘢痕 瘢痕疙瘩 瘢痕治疗 

分 类 号：R622[医药卫生—整形外科]