木糖氧化无色杆菌医院感染的临床分析  

Clinical analysis of nosocomial infection of Achromobacter xylose oxidation

作　　者：余素娟 杨玮[1] 闫涛[1] 齐艳[1] YU Su-juan;YANG Wei;YAN Tao;QI Yan(Medical Laboratory Center,Hangzhou Hospital of Traditional Chinese Medicine,Zhejiang 310007,China)

机构地区：[1]杭州市中医院医学检验中心,浙江310007

出　　处：《中国卫生检验杂志》2023年第2期202-204,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的 分析浙江某医院木糖氧化无色杆菌出现院内感染的易感因素、防治措施及耐药情况,为临床提供有效用药依据。方法 回顾性分析2016年6月—2021年6月浙江某医院分离出的24株木糖氧化无色杆菌。结果 木糖氧化无色杆菌所致感染与患者年龄、伴有基础疾病、接受侵入性医疗操作、使用大量广谱抗菌药物紧密相关;耐药率低于15%的药物为磺胺甲恶唑/甲氧苄啶、哌拉西林/他唑巴坦、替加环素、头孢哌酮/舒巴坦;阿莫西林/棒酸、左氧氟沙星和亚胺培南耐药率均低于30%。结论 医院感染木糖氧化无色杆菌,以呼吸道感染的ICU老年患者为主;痰液标本检出率最高,药敏耐药性高且表现多重耐药性;治疗上可优先考虑β-内酰胺酶类/β-内酰胺酶抑制剂、磺胺甲恶唑/甲氧苄啶、甘氨酰环素类、碳青霉烯类等抗菌药物。Objective This paper aims to analyze the susceptibility factors, prevention and treatment measures and drug resistance of Achromobacter xylose oxidation in nosocomial infection in a hospital of Zhejiang province and provide effective evidence for clinical use. Methods A total of 24 Achromobacter xylose oxidation isolated from a hospital in Zhejiang Province from June 2016 to June 2021 were analyzed retrospectively. Results The age, underlying diseases, invasive medical procedures and the use of a large number of broad-spectrum antibiotics were closely related to the infection of Achromobacter xylose oxidation. The drug resistance rate was lower than 15% for sulfamethoxazole/trimethoprim, piperacillin/tazobactam, tigacycline and cefoperazone/sulbactam. The drug resistance rates of amoxicillin/pauconic acid, levofloxacin and imipenem were all lower than 30%. Conclusion Nosocomial infection with Achromobacter xylose oxidation is mainly in elderly ICU patients with respiratory tract infection. The sputum specimen detection rate was the highest, and the drug resistance was high and showed multiple drug resistance. In the treatment of nosocomial infection caused by Achromobacter xylose oxidation, antibacterial drugs such as β-lactamase/β-lactamase inhibitors, sulfamethoxazole/trimethoprimethidine, glycylclin and carbapenems can be given priority.

关 键 词：木糖氧化无色杆菌 院内感染 抗菌药物 耐药机制 

分 类 号：R446[医药卫生—诊断学]