超敏C-反应蛋白、中性粒细胞与淋巴细胞比值与新生儿化脓性脑膜炎患儿预后不良的相关性  

Correlation between hypersensitive C-reactive protein,neutrophil and lymphocyte ratio and poor prognosis in children with neonatal purulent meningitis

作　　者：陈芳芳[1] 鲁萍[1] 吕俊英[1] 李崇寿[1] CHEN Fang-fang;LU Ping;LV Jun-ying;LI Chong-shou(Department of Neonatology,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325400,China)

机构地区：[1]温州医科大学附属第二医院新生儿科,浙江温州325400

出　　处：《中国卫生检验杂志》2023年第3期341-345,共5页Chinese Journal of Health Laboratory Technology

摘　　要：目的 分析血清超敏C-反应蛋白(hs-CRP)、中性粒细胞与淋巴细胞比值(NLR)与新生儿化脓性脑膜炎(NPM)患儿预后不良的关系。方法 选取温州医科大学附属第二医院2019年4月—2021年6月166例NPM患儿为研究对象,并对患儿随访12个月,着重评估有无并发症或神经系统后遗症及神经系统影像学表现,根据随访结果分为预后不良组和预后良好组。采用全自动血液分析仪检测2组患儿中性粒细胞值、淋巴细胞值,计算NLR,并经散射比浊法检测hs-CRP水平;采用点二列相关性、logistic回归分析血清hs-CRP、NLR水平与NPM患儿预后不良有关;采用受试者工作特征(ROC)曲线预测血清hs-CRP、NLR预测NPM患儿预后不良的价值。结果 随访12个月,166例NPM患儿均无病死,其中51例预后不良,占30.72%;预后不良组血清hs-CRP、NLR水平均高于预后良好组,差异有统计学意义(P<0.05);采用点二列相关性分析,血清hs-CRP、NLR水平与NPM患儿预后不良有关(r值分别为0.627、0.418,P<0.001);logistic回归分析检验,血清hs-CRP、NLR过表达与NPM患儿预后不良有关(P<0.05);绘制ROC曲线,结果显示,血清hs-CRP、NLR水平单独及联合预测NPM患儿预后不良的曲线下面积(AUC)分别为0.881、0.739、0.899,具有一定的价值。结论 血清hs-CRP、NLR过表达与NPM患儿预后不良存在一定的联系,两指标过表达可提示NPM患儿预后不良的风险。Objective This paper aims to analyze the relationship between serum hypersensitive C-reactive protein(hs-CRP), neutrophil and lymphocyte ratio(NLR) and poor prognosis of children with neonatal purulent meningitis(NPM). Methods A total of 166 children with NPM in the Second Affiliated Hospital of Wenzhou Medical University from April 2019 to June 2021 were selected as the study subjects, and the children were followed up for 12 months. The evaluation focused on the presence of complications or neurological sequelae and neurological imaging findings. According to the follow-up results, the patients were divided into poor prognosis group and good prognosis group. The values of neutrophils and lymphocytes were measured by automatic blood analyzer, NLR was calculated, and the hs-CRP level was detected by nephelometry;point binary correlation and logistic regression were used to analyze the relationship between serum hs-CRP and NLR levels and the poor prognosis of children with NPM;the receiver operating characteristic(ROC) curve was used to predict the value of serum hs-CRP and NLR in predicting the poor prognosis of children with NPM. Results All 166 children with NPM did not die from illness after 12 months of follow-up. Among them, 51 cases had poor prognosis, accounting for 30.72%;the levels of serum hs-CRP and NLR in the poor prognosis group were higher than those in the good prognosis group and the difference was statistically significant(P<0.05);point two column correlation analysis showed that the levels of serum hs-CRP and NLR were related to the poor prognosis of children with NPM(r=0.627, r=0.418, P<0.001);logistic regression analysis showed that the overexpression of serum hs-CRP and NLR was related to the poor prognosis of children with NPM(P<0.05);the ROC curve was drawn, and the result showed that the area under the curve(AUC) of serum hs-CRP and NLR levels alone and in combination to predict poor prognosis in children with NPM were 0.881, 0.739 and 0.899, respectively, which had certain value. Conclusi

关 键 词：新生儿 化脓性脑膜炎 超敏C-反应蛋白 中性粒细胞与淋巴细胞比值 预后 

分 类 号：R722.1[医药卫生—儿科]