供肝保存与功能维护助力肝移植发展  

Liver graft preservation and functional maintenance accelerate the development of liver transplantation

作　　者：谢炎 蒋文涛[1] Xie Yan;Jiang Wentao(Department of Liver Transplantation,Tianjin First Center Hospital,Tianjin Key Laboratory for Organ Transplantation,Research Institute of Transplant Medicine,Nankai University,Tianjin 300190,China)

机构地区：[1]天津市第一中心医院肝移植科,天津市器官移植重点实验室,南开大学移植医学研究院,天津300190

出　　处：《器官移植》2023年第2期201-206,共6页Organ Transplantation

基　　金：国家自然科学基金面上项目(81870444);天津市卫生健康委员会重点学科专项(TJWJ2022XK016);天津市自然科学基金面上项目(20JCYBJC01010)。

摘　　要：肝移植作为终末期肝病的有效治疗方法已在世界范围内广泛开展,并逐渐取得普遍认可。随着肝移植手术技术趋于成熟,术后并发症发生率逐步降低,受者的短期和长期预后持续改善。然而,器官的供应与需求之间一直存在着巨大鸿沟,是限制肝移植手术开展的重要原因。国内肝移植手术量逐年上升,供肝短缺问题日益突出,边缘供肝越来越多地应用于临床。近年来,供者器官的选择标准、器官的保存及功能维护技术不断完善。本文将从供肝保存、功能维护两方面,结合二者近年来的技术发展和研究成果,评述不同技术的应用情况和发展趋势,为进一步提高移植物和受者生存率,促进我国肝移植的发展提供参考。As an effective treatment for end-stage liver disease,liver transplantation has been widely carried out worldwide and gradually captivated widespread recognition.With the advancement of liver transplantation techniques,the incidence of postoperative complications has been gradually declined,and the short-term and long-term prognosis of recipients have been constantly improved.However,a huge gap has existed between the supply and demand of donor organs,which is a major factors restricting the development of liver transplantation.The amount of liver transplantation operation in China is increasing year by year,the shortage of donor liver is becoming more and more prominent,and marginal donor liver is increasingly used in clinic.In recent years,the selection criteria of donor organs,organ preservation and functional maintenance have been continuously improved.In this article,the application and development trend of different techniques were reviewed from the perspectives of donor liver preservation and functional maintenance,and recent technical development and research results were summarized,aiming to provide reference for further enhancing the survival rate of grafts and recipients and promoting the development of liver transplantation in China.

关 键 词：肝移植 边缘供肝 静态冷保存 机械灌注 缺血-再灌注损伤 功能维护 基因治疗 干细胞疗法 

分 类 号：R617[医药卫生—外科学]