肢体保存技术的研究现状及进展  

Research status and progress on limb preservation technology

作　　者：李雨虹 赵闻雨 曾力 Li Yuhong;Zhao Wenyu;Zeng Li(Department of Organ Transplantation,the First Affiliated Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院器官移植科,上海200433

出　　处：《器官移植》2023年第2期295-299,共5页Organ Transplantation

基　　金：国家自然科学基金面上项目(81770744)。

摘　　要：肢体再植和移植是挽救创伤性肢体离断的首选治疗方法,而安全有效的肢体保存是肢体再植和移植成功的关键。静态低温保存技术是目前肢体保存的金标准,但保存时间较短,已无法满足临床的需要。随着近年来器官保存领域的快速发展,一些新的保存技术如深低温冷冻保存、过冷保存和机械灌注保存等相继出现,但目前这些技术多应用于实体器官的保存,而在包括肢体在内的带血管的复合组织移植移植物保存方面的研究较少。本文就静态低温保存及机械灌注保存在肢体保存中的研究现状及进展进行综述,以期为肢体保存技术的临床应用提供参考,促进肢体再植和移植的发展。Limb replantation and transplantation is the optimal treatment for traumatic limb amputation.Safe and effective limb preservation is the key factor to determine the success of limb replantation and transplantation.Currently,static cold storage is the gold standard of limb preservation.However,the preservation time is short,which may no longer meet clinical requirements.With rapid development of organ preservation in recent years,novel preservation technologies,such as ultra-low temperature preservation,supercooling preservation and mechanical perfusion preservation,have successively emerged.However,at present,these techniques are primarily applied to the preservation of solid organs rather than composite tissue allografts with blood vessels including limbs.In this article,research status and progress on the application of static cold storage and mechanical perfusion preservation in limb preservation were reviewed,aiming to provide reference for clinical application of limb preservation technology and promote the development of limb replantation and transplantation.

关 键 词：肢体再植 肢体移植 肢体保存 带血管的复合组织移植 静态冷保存 深低温冷冻保存 过冷保存 机械灌注 

分 类 号：R617[医药卫生—外科学] R323.7[医药卫生—临床医学]