氢分子及其制品对肺移植保护作用的研究进展  

Research progress on protective effect of hydrogen molecule and its products on lung transplantation

作　　者：刘孟根 刘沛直 唐宏涛 黄桁 田东 Liu Menggen;Liu Peizhi;Tang Hongtao;Huang Heng;Tian Dong(Department of Thoracic Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;不详)

机构地区：[1]四川大学华西医院胸外科,成都610041 [2]川北医学院附属医院心肺移植研究室

出　　处：《器官移植》2023年第2期300-304,共5页Organ Transplantation

基　　金：四川省科技厅重点研发项目(23ZDYF2875);国家级大学生创新创业计划训练项目(202210634058)。

摘　　要：肺移植术后缺血-再灌注损伤是导致原发性移植物功能障碍的主要原因,进而会降低肺移植受者的移植肺功能和总体生存率。氢分子作为一种生理调节性分子,具有抗炎、改善氧化应激、减轻直接细胞损伤和缓解上皮细胞水肿等作用。近年来,越来越多的研究证明氢分子及其制品(主要是氢气和富氢溶液)可以显著改善肺移植术后缺血-再灌注损伤等并发症。本文就氢分子及其制品在肺移植中的保护作用及具体机制进行回顾总结,旨在为氢分子及其制品作为一种新的肺移植相关并发症治疗手段提供理论依据,进而改善肺移植受者的总体预后及生活质量。Ischemia-reperfusion injury after lung transplantation is the main cause of primary graft dysfunction,which will subsequently reduce the function of lung allograft and lower the overall survival rate of lung transplant recipients.As a physiological regulatory molecule,hydrogen molecule has the functions of anti-inflammation,easing oxidative stress,alleviating direct cell injury and mitigating epithelial edema.Recent studies have demonstrated that hydrogen molecule and its products(hydrogen and hydrogen-rich solution)could significantly mitigate ischemiareperfusion injury and postoperative complications after lung transplantation.In this article,the protective effect and exact mechanism of hydrogen molecule and its products in lung transplantation were reviewed,aiming to provide theoretical basis for the application of hydrogen molecule and its products as a novel treatment for lung transplantation-related complications,enhance the overall prognosis and improve the quality of life of lung transplant recipients.

关 键 词：肺移植 氢分子 富氢溶液 缺血-再灌注损伤 热缺血期 冷缺血期 离体肺灌注 原发性移植物功能障碍 

分 类 号：R617[医药卫生—外科学] R563[医药卫生—临床医学]