人体子宫移植相关要点讨论  

Highlights of human uterus transplantation

作　　者：刘宇 丁岩 张旭垠 华克勤 Liu Yu;Ding Yan;Zhang Xuyin;Hua Keqin(Department of Gynecological Oncology,Obstetrics&Gynecology Hospital of Fudan University,Shanghai 200090,China)

机构地区：[1]复旦大学附属妇产科医院妇科肿瘤科,上海200090

出　　处：《器官移植》2023年第2期305-312,共8页Organ Transplantation

基　　金：国家重点研发计划(VEG157011);国家自然科学基金青年科学基金(8190061150)。

摘　　要：子宫移植作为一种新兴的实体器官移植,已成为子宫性不孕女性获取生物学后代的重要方式。子宫移植手术本身存在血管蒂提取、器官灌注及血管缝合等方面的技术挑战,但随着子宫移植动物造模及尸体移植手术的开展及应用,子宫移植供受者的选择、子宫血管的选择、子宫移植的并发症及其防治、移植物活力评估、妊娠及分娩时机的选择、子宫切除时机的选择及供受者心理健康及后代健康等问题越发成为讨论的新热点。本文根据全球现有人体子宫移植数据及结局,就以上热点问题进行综述,以期为促进国内人体子宫移植研究的开展和取得更长远的进步提供参考。As a novel solid organ transplantation,uterus transplantation has become an important approach for women with uterine infertility to obtain biological offspring.Multiple technological challenges exist in uterus transplantation,such as acquisition of vascular pedicle,organ perfusion and vascular suture,etc.However,with the development and application of uterus transplantation in animal model and transplantation in human cadavers,a lot of problems have become new hot topics of discussion,such as the selection of uterus transplantation donors and recipients,selection of uterine vessels,prevention and treatment of complications after uterus transplantation,evaluation of graft vitality,timing of pregnancy and delivery,timing of hysterectomy,mental health of donors and recipients and offspring health,etc.According to current data and outcomes of human uterus transplantation worldwide,these hot topics were reviewed in this article,aiming to provide reference for promoting the development and progress of human uterus transplantation research in China.

关 键 词：子宫移植 供者选择 子宫血管 免疫抑制治疗 并发症 子宫活力 妊娠 活产分娩 

分 类 号：R617[医药卫生—外科学] R711.74[医药卫生—临床医学]