慢性阻塞性肺疾病相关动物模型研究进展  

Development of ananimal model for chronic obstructive pulmonary-related disease

作　　者：周利润 崔晓兰[1] ZHOU Lirun;CUI Xiaolan(Institute of Traditional Chinese Medicine,Chinese Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验动物学报》2022年第8期1121-1127,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家重点研发计划(2018YFE0102300);中国中医科学院科技创新工程(C12021A04606)。

摘　　要：慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)是指在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的基础上持续恶化,并超出了日常变异范围,目前尚无标准COPD及AECOPD动物模型。AECOPD动物模型是研究AECOPD病理机制及寻找有效诊疗手段的基础。COPD制备方法包括单纯烟熏法、烟熏联合气管滴注脂多糖法、汽车尾气吸入法等。AECOPD制备方法主要是在COPD模型基础上进行细菌病毒感染。该文梳理总结了国内外COPD及AECOPD动物模型的制备方法、评价指标,力争为科研和医务工作者提供有益参考。Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)refers to the continuous deterioration of chronic obstructive pulmonary disease(COPD)beyond the scope of daily variation.At present,there are no standard animal models for COPD or AECOPD.The animal model for AECOPD is applied in studying the pathological mechanisms of AECOPD and determining effective diagnosis and treatment method.COPD preparation method include simple passive smoking,passive smoking combined with tracheal instillation of the lipopolysaccharide method,and automobile exhaust inhalation.AECOPD model preparation is usually bacterial or viral infection of the COPD model.This brief review focuses on COPD and AECOPD animal models from the perspectives of model creation and evaluation,providing useful information for researchers and medical practitioners.

关 键 词：慢性阻塞性肺疾病 慢性阻塞性肺疾病急性加重期 动物模型建立 

分 类 号：Q95-33[生物学—动物学]