N-乙醯半胱氨酸在抗幽門螺桿菌治療中的應用價值  

The effect of N-acetyl cysteine on eradication treatment of helicobacter pylori

作　　者：徐義祥 余漢濠 CHOI I Cheong;YU Hon Ho(Internal Medicine Department,Kiang Wu Hospital,Macao,China)

机构地区：[1]澳門鏡湖醫院消化内科,中国

出　　处：《镜湖医学》2012年第2期27-28,共2页MEDICAL JOURNAL OF KIANG WU

摘　　要：目的觀察N-乙酰半胱氨酸在抗幽門螺桿菌治療中的臨床應用價值。方法按隨機分組方法對胃黏膜活檢發現Hp陽性患者分成兩組,對照組給予Nexium 20mg bid,Amoxil 1000mg bid,Karicin 1000mg bid共14天的根治療法,其中一組為Fluimucil試驗組,給予Fluimucil 0.6 qd及上述三聯療法共7天治療,試驗結束後4週進行13C呼氣試驗作根治效果檢測。結果40名試驗組患者和55名對照組患者經過抗Hp治療後的治癒率分別為91.6%(33人)和85.4%(41人),並具有明顯統計學意義(P<0.05)。結論N-乙酰半胱氨酸在抗幽門螺桿菌治療中的應用有效。Objective To investigate the effect of N-acetyl cysteine in eradication of Helicobacter pylori infection.Methods Through the endoscopy biopsy,the Hp positive patients were randomized into two groups.The control group was given nexium 20mg bid,amoxil 1000mg bid,karicin 1000mg bid for 14-day eradication therapy.While the fluimucil(AC group)was given fluimucil 0.6 qd plus 7-day eradication treatment.The effects were evaluated and compared four weeks after the completion of the treatment through 13C breath test.Results After the Hp eradication treatment,the success rates were 91.6%(33/40)in AC group and 85.4%(41/55patients)in control group respectively with statistical significance(P<0.05).Conclusion N-acetyl cysteine might be effec-tive in eradication of helicobacter pylori infection.

关 键 词：N-乙酰半胱氨酸 幽門螺桿菌 抗幽門螺桿菌治療 

分 类 号：R95[医药卫生—药学]