基于纳米技术的新型超声造影剂在肌肉骨骼关节疾病诊疗中的应用  

Application of novel ultrasound contrast agents based on nanotechnology in diagnosis and treatment of musculoskeletal joint diseases

作　　者：汤晓轶 赵梦鑫 李威[2] 赵佳琦 TANG Xiao-yi;ZHAO Meng-xin;LI Wei;ZHAO Jia-qi(Department of Ultrasound,The Second Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200003,China;Department of Nanomedicine&Shanghai Key Laboratory of Cell Engineering,Naval Medical University(Second Military Medical University),Shanghai 200433,China;Department of Ultrasound,Shanghai Fourth People’s Hospital Affiliated to Tongji University,Shanghai 200434,China)

机构地区：[1]海军军医大学(第二军医大学)第二附属医院超声诊断科,上海200003 [2]海军军医大学(第二军医大学)纳米医学研究室,上海细胞工程重点实验室,上海200433 [3]同济大学附属上海市第四人民医院超声医学科,上海200434

出　　处：《海军军医大学学报》2023年第2期143-149,共7页Academic Journal of Naval Medical University

基　　金：国家自然科学基金(81501492);上海市自然科学基金(20ZR1457900);海军军医大学(第二军医大学)第二附属医院人才建设三年行动计划——“金字塔”人才工程军事医学人才项目(1009)。

摘　　要：随着超声医学和纳米医学的发展,超声造影技术已进入一个全新的发展阶段,新材料的设计和精细纳米材料的制备进一步促进了纳米级超声造影剂的临床应用。相较于传统的超声造影技术,基于纳米技术的新型超声造影剂具有生物相容性、血清稳定性和显影时间持久性等优势,纳米级超声造影剂技术在恶性肿瘤等疾病的精准诊疗一体化方面表现出令人惊喜的效果。总结笔者长期临床实践及文献报道发现,纳米级超声造影剂在肌肉骨骼关节疾病领域有潜在价值,有望为肌肉骨骼关节疾病的诊疗提供更可靠的指导。The progression of ultrasonic medicine and nanomedicine has led contrast-enhanced ultrasound technology to a brand new stage. The design of new materials and preparation of fine nano-materials further promote the clinical application of nanoscale ultrasound contrast agents. Compared with traditional ultrasound contrast agents, nanotechnology-based novel ultrasound contrast agents have advantages such as excellent biocompatibility, serum stability, and long-lasting time. The technology of nanoscale ultrasound contrast agent was found to have an impressive role in the accurate diagnosis and treatment of malignant tumors. The authors, based on long-term clinical experience and literature, reviewed the potential value of nanoscale ultrasound contrast agents in managing musculoskeletal joint diseases, hoping to provide reliable guidance for the diagnosis and treatment of musculoskeletal joint diseases.

关 键 词：超声造影 超声造影剂 纳米技术 肌骨超声 分子影像 

分 类 号：R445.1[医药卫生—影像医学与核医学] R68[医药卫生—诊断学]