血清CHI3L1、SOCS3对2型糖尿病患者早期糖尿病肾病的预测价值  

Predictive value of ser um CHI3L1 and SOCS3 in early diabetic nephropathy in patients with type 2 diabetes

作　　者：张钢[1] 王海芳[1] 杨志森 ZHANG Gang;WANG Haifang;YANG Zhisen(First Department of Endocrinology,First Hospital of Handan,Handan,Hebei 056000,China;Department of General Surgery,First Hospital of Handan,Handan,Hebei 056000,China)

机构地区：[1]河北省邯郸市第一医院内分泌一科,河北邯郸056000 [2]河北省邯郸市第一医院综合外科,河北邯郸056000

出　　处：《国际检验医学杂志》2023年第5期561-564,570,共5页International Journal of Laboratory Medicine

基　　金：河北省邯郸市科学技术研究与发展计划项目(19422083010-4);河北省科学技术成果(20220038)。

摘　　要：目的分析血清壳多糖酶3样蛋白1(CHI3L1)、细胞因子信号转导抑制因子3(SOCS3)对2型糖尿病患者早期糖尿病肾病的预测价值。方法将2019年12月至2021年12月该院收治的98例2型糖尿病患者作为研究对象,并根据尿清蛋白排泄率(UAER)将患者分为单纯糖尿病组(n=55)、早期糖尿病肾病组(n=43),同时另选取同期来该院进行体检的50例健康者作为对照组。所有研究对象入院后均检测血清CHI3L1、SOCS3水平。分析比较各组临床资料和实验室指标,采用受试者工作特性曲线(ROC曲线)评估血清CHI3L1、SOCS3对2型糖尿病患者早期糖尿病肾病的预测价值,多因素Logistic回归分析探讨影响2型糖尿病患者早期糖尿病肾病的相关因素。结果早期糖尿病肾病组患者血清CHI3L1、SOCS3水平均明显高于单纯糖尿病组、对照组,差异有统计学意义(P<0.05);单纯糖尿病组血清CHI3L1、SOCS3水平均明显高于对照组,差异有统计学意义(P<0.05)。ROC曲线结果显示,血清CHI3L1预测2型糖尿病患者早期糖尿病肾病的曲线下面积、灵敏度、特异度分别为0.768、93.02%、52.73%;血清SOCS3预测2型糖尿病患者早期糖尿病肾病的曲线下面积、灵敏度、特异度分别为0.830、93.02%、61.82%,两者联合预测2型糖尿病患者早期糖尿病肾病的曲线下面积、灵敏度、特异度分别为0.920、88.37%、87.27%。多因素Logistic回归分析结果得出,血清CHI3L1(OR=3.90,95%CI:1.90~7.98)、SOCS3(OR=4.10,95%CI:1.86~9.01)均为影响2型糖尿病患者出现早期糖尿病肾病的危险因素(P<0.05)。结论血清CHI3L1、SOCS3在2型糖尿病患者中均升高,且2型糖尿病合并糖尿病肾病患者血清CHI3L1、SOCS3水平更高,二者是2型糖尿病患者早期糖尿病肾病的相关因素,同时对2型糖尿病患者早期糖尿病肾病具有较高的预测价值。Objective To explore the predictive value of serum chitinase 3-like protein 1(CHI3L1)and suppressor of cytokine signaling 3(SOCS3)in early diabetic nephropathy in patients with type 2 diabetes.Methods A total of 98 patients with type 2 diabetes who were admitted to the hospital from December 2019 to December 2021 were selected as the research subjects,and the patients were divided into simple diabetes group(n=55)and early diabetic nephropathy group(n=43)according to the urinary albumin excretion rate(UAER),and 50 healthy people who came to a hospital for physical examination during the same period were selected as the control group.Serum CHI3L1 and SOCS3 levels were detected in all included subjects after admission.The clinical data and laboratory indicators of each group were analyzed and compared,and the receiver operating characteristic curve(ROC curve)was used to evaluate the predictive value of serum CHI3L1 and SOCS3 on early diabetic nephropathy in patients with type 2 diabetes.The related factors of early diabetic nephropathy in patients with type 2 diabetes were investigated by multivariate Logistic regression analysis.Results The levels of serum CHI3L1 and SOCS3 in early diabetic nephropathy group were significantly higher than those in simple diabetic group and control group,the difference was statistically significant(P<0.05).Serum CHI3L1 and SOCS3 levels in simple diabetes group were significantly higher than those in control group,and the difference was statistically significant(P<0.05).The ROC curve results showed that the area under the curve,sensitivity,and specificity of serum CHI3L1 for predicting early diabetic nephropathy in patients with type 2 diabetes were 0.768,93.02%,and 52.73%,respectively.The area under the curve,sensitivity,and specificity of serum SOCS3 for predicting early diabetic nephropathy in patients with type 2 diabetes were 0.830,93.02%,and 61.82%,respectively.The area under the curve,sensitivity,and specificity of the two combined to predict early diabetic nephropathy in pati

关 键 词：壳多糖酶3样蛋白1 细胞因子信号转导抑制因子3 2型糖尿病 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]