严重烧伤后肠屏障功能障碍的研究进展  

Research progress on intestinal barrier dysfunction after severe burn

作　　者：李大伟 申传安[2] 刘兆兴[1,2] 臧宇 张文 马景龙[1,2] Li Dawei;Shen Chuanan;Liu Zhaoxing;Zang Yu;Zhang Wen;Ma Jinglong(PLA Medical School,Beijing 100853,China;Department of Burns and Plastic Surgery,Fourth Medical Centre of PLA General Hospital,Beijing 100048,China)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第四医学中心烧伤整形医学部,北京100048

出　　处：《中华损伤与修复杂志（电子版）》2023年第1期65-68,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：军队后勤科研重大项目(ALB18J001);北京自然科学基金项目(7204311);国家自然科学基金项目(82072169)。

摘　　要：肠屏障由肠道上皮屏障、微生物屏障和黏膜免疫屏障组成。严重烧伤后低灌注性缺血缺氧、炎症因子、机体营养不良和菌群失调等多种因素均可导致肠屏障功能障碍,是引起细菌移位和肠源性感染,诱发脓毒症和多脏器功能衰竭的重要原因,严重影响患者预后。近年来,国内外对严重烧伤后肠道屏障功能损伤的机制和危害取得了较多的研究进展,本文对此进行综述。The intestinal barrier consists of intestinal epithelial barrier,intestinal microbial barrier and mucosal immune barrier.Many factors such as low perfusion ischemia and hypoxia,inflammatory cytokines,malnutrition and flora imbalance after severe burn can lead to intestinal barrier dysfunction,which is responsible for bacterial translocation and intestinal infection and vulnerable to sepsis and multiple organ failure,and seriously affects the prognosis of patients.In recent years,more research progress has been made on the mechanism and harm of intestinal barrier function injury after severe burn,which is reviewed in this paper.

关 键 词：烧伤 肠黏膜 脓毒症 肠道 屏障功能 菌群失调 

分 类 号：R47[医药卫生—护理学]