不同年龄心血管疾病患者血浆半乳凝集素3与低密度脂蛋白胆固醇的相关性  

Relationship between plasma galectin 3 and low-density lipoprotein cholesterol stratified by ages in patients with cardiovascular disease

作　　者：张一帆 李长平 张莉莉 陈忠 ZHANG Yifan;LI Changping;ZHANG Lili;CHEN Zhong(Department of Cardiology,the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China;Department of Cardiology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong,China)

机构地区：[1]上海交通大学医学院附属第六人民医院心血管内科,上海200233 [2]中山大学孙逸仙纪念医院心血管内科,广东广州510120

出　　处：《检验医学》2023年第1期8-13,共6页Laboratory Medicine

基　　金：上海健康医学院教学建设(临床医学本科心血管专业教学团队建设)项目;上海健康医学院双语课程(诊断学)项目。

摘　　要：目的探讨不同年龄心血管疾病(CVD)患者半乳凝集素3(Gal3)与低密度脂蛋白胆固醇(LDL-C)的相关性。方法选取2018年1月—2020年8月上海市第六人民医院CVD住院患者257例,根据年龄将所有患者分为34~54岁组(58例)、55~64岁组(64例)、65~74岁组(67例)、75~94岁组(68例)。收集所有患者的一般资料(性别、年龄、用药情况、吸烟史和基础疾病史等),检测其白细胞(WBC)计数、血红蛋白(Hb)、氨基末端B型钠尿肽原(NT-proBNP)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、LDL-C、高密度脂蛋白胆固醇(HDL-C)、Gal3水平。对所有患者进行CVD危险分层,根据有无LDL-C异常分为LDL-C异常组(156例)和LDL-C正常组(101例)。根据患者有无心力衰竭分为心力衰竭组(63例)和对照组(189例)。采用Spearman相关分析评估各项指标之间的相关性。采用Logistic回归分析评估LDL-C异常的影响因素。结果34~54岁组、55~64岁组、65~74岁组、75~94岁组之间心力衰竭比例、血管紧张素转换酶抑制剂(ACEI)或血管紧张素Ⅱ受体阻滞剂(ARB)使用比例、β受体阻滞剂使用比例和NT-proBNP、Hb、TC、TG、LDL-C水平差异均有统计学意义(P<0.05),其他各项指标差异均无统计学意义(P>0.05)。Spearman相关分析结果显示,年龄与Gal3、TC、TG、LDL-C均呈负相关(P<0.05),与HDL-C无相关性(P=0.551);在55~64岁和65~74岁的CVD患者中,Gal3与LDL-C呈正相关(P<0.001);在未服用降脂药物的CVD患者中,Gal3与LDL-C呈正相关(P<0.001)。Logistic回归分析结果显示,在65~74岁组中,Gal3水平升高和有高血压史是LDL-C异常的独立影响因素[比值比(OR)值分别为1.977、4.480,95%可信区间(CI)分别为1.157~3.379、1.335~15.032]。心力衰竭组年龄和Gal3水平显著高于对照组(P<0.05),LDL-C水平显著低于对照组(P<0.05)。心力衰竭组和对照组Gal3与LDL-C均呈正相关(r值分别为0.307、0.298,P<0.05)。结论CVD患者Gal3与LDL-C的相关性与年龄有关�Objective To investigate the relationship between plasma galectin 3(Gal3)and lowdensity lipoprotein cholesterol(LDL-C)stratified by ages in patients with cardiovascular disease(CVD).Methods From January 2018 to August 2020,257 inpatients in the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were enrolled.These patients were classified into 4 groups,34-54-yearold group(58 cases),55-64-year-old group(64 cases),65-74-year-old group(67 cases)and 75-94-year-old group(68 cases).Basic data,including sex,age,drug usage,smoking history and underlying diseases,were collected.White blood cell(WBC)count,hemoglobin(Hb),N-terminal pro-B-type natriuretic peptide(NTpro BNP),glycated hemoglobin A1c(Hb A1c),total cholesterol(TC),triglyceride(TG),LDL-C and highdensity lipoprotein cholesterol(HDL-C)were determined,and plasma Gal3 was determined as well.All the patients were stratified in the risk of CVD and were classified into LDL-C abnormal group(156 cases)and LDL-C normal group(101 cases).According to whether patients had heart failure,they were classified into heart failure group(63 cases)and control group(189 cases).Spearman correlation analysis was used to assess the correlation between the indicators.Logistic regression analysis was used to evaluate the predictors of LDL-C abnormalities.Results Among the 4 age groups,the proportions of heart failure,ACEI or ARB usage andβreceptor inhibitor usage and NTpro BNP,Hb,TC,TG and LDL-C levels had statistical significance(P<0.05),and the other indicators had no statistical significance(P>0.05).The results of Spearman correlation analysis showed that Gal3,TC,TG and LDL-C were negatively related to age in patients with CVD(P<0.05),and age had no correlation with HDL-C(P=0.551).There was a positive correlation between Gal3 and LDL-C in 55-64-year-old and 65-74-year-old groups(P<0.001).In CVD patients who were not taken lipid-lowering drugs,Gal3 was positively correlated with LDL-C(P<0.001).Logistic regression analysis showed that the increased G

关 键 词：半乳凝集素3 低密度脂蛋白胆固醇 心血管疾病 血脂异常 

分 类 号：R446.1[医药卫生—诊断学]