武汉市某三级甲等医院人偏肺病毒感染患儿实验室检测结果和临床特征分析  

Clinical and laboratory characteristics of human metapneumovirus infection children in a Grade A Class 3 hospital in Wuhan

作　　者：魏瑞 袁旭 田学文 鲁艳军[1] WEI Rui;YUAN Xu;TIAN Xuewen;LU Yanjun(Department of Clinical Laboratory,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China)

机构地区：[1]华中科技大学同济医学院附属同济医院检验科,湖北武汉430000

出　　处：《检验医学》2023年第1期18-22,共5页Laboratory Medicine

摘　　要：目的回顾分析呼吸道人偏肺病毒(hMPV)感染患儿实验室检测结果和临床特征,为感染防控提供参考。方法收集2021年6月—2022年2月华中科技大学同济医学院附属同济医院3365例疑似呼吸道感染患儿鼻咽拭子样本,采用多重聚合酶链反应(PCR)结合毛细管电泳片段分析技术,检测甲型流感病毒(FLU A)、呼吸道合胞病毒(RSV)、人鼻病毒(HRV)和hMPV等13种常见呼吸道病毒的特异性核酸序列。回顾分析hMPV阳性病例流行病学资料、临床表现、实验室和影像学检查结果、治疗和疾病转归情况。结果3365例样本中,hMPV阳性54例(1.6%),剔除重复或无关病例后,最终纳入51例hMPV阳性病例进行分析,患儿年龄52 d~10岁。51例患儿中,单纯hMPV感染35例(68.6%)、合并其他病毒感染16例(31.4%)。有60.8%的患儿有呼吸道感染史,临床表现以咳嗽、发热为主;有41例患儿肺部可闻及啰音;有14例患儿白细胞计数升高,11例淋巴细胞计数降低,19例C反应蛋白升高,所有患儿肌酐均低于参考区间;有29例患儿伴肝功能异常。单纯hMPV感染患儿与合并其他病毒感染患儿相关指标和临床症状差异无统计学意义(P>0.05);所有患儿经抗病毒或对症支持等综合治疗后均好转出院。结论hMPV是引起武汉地区儿童急性呼吸道感染的重要病原体之一,患儿经相关治疗后一般预后良好。Objective To retrospectively analyze the clinical and laboratory characteristics of human metapneumovirus(hMPV)infection children,and to provide a reference for infection prevention and control.Methods Multiple polymerase chain reaction(PCR)combined with capillary electrophoresis fragment analysis was used for 13 common respiratory pathogens such as influenza A virus(FLU A),respiratory syncytial virus(RSV),human rhinovirus(HRV)and hMPV in 3365 nasopharyngeal swab samples from the children with respiratory tract infection in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,from June 2021 to February 2022.The epidemiological data,clinical presentation,laboratory and imaging examination results,treatment and outcome of hMPV positive cases were analyzed.Results Totally,54hMPV positive samples accounted for 1.6%of 3365 cases.Totally,51 hMPV positive cases(52 d-10-year-old)were selected for the analysis after eliminating duplicate and unrelated case,including 35 simply hMPV positive cases(68.6%)and 16 cases combined with other viral infections(31.4%).There were 60.8%patients with a previous history of respiratory tract infection,and the clinical manifestations were mainly cough and fever.There were 41patients undergoing lung auscultation with abnormalities.Clinical laboratory results showed that 14 patients had increased white blood cell count,11 patients with decreased lymphocyte count,19 patients with increased C-reactive protein,29 patients with abnormal liver function and low creatinine.Further analysis of the above main indicators showed no statistical significance between the children with simple hMPV infection group and those with other viral infections.All the children were discharged after comprehensive treatment such as antiviral and symptomatic support.Conclusions The hMPV is one of the important pathogens causing acute respiratory tract infection in children in Wuhan.Most children could have a good prognosis.

关 键 词：人偏肺病毒 实验室检测 临床特征 儿童 

分 类 号：R373.1[医药卫生—病原生物学]