非编码RNA调控糖尿病创面愈合机制的研究进展  

Research advances on the mechanism of non-coding RNA regulated diabetic wound healing

作　　者：李晓亮[1] 谢江帆 叶向阳 李琰光 刘德伍[2] Xiaoliang Li;Jiangfan Xie;Xiangyang Ye;Yanguang Li;Dewu Liu(Department of Burns,Zhengzhou First People's Hospital,Zhengzhou 450004,China;Medical Center of Burn Plastic and Wound Repair,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]郑州市第一人民医院烧伤科,郑州450004 [2]南昌大学第一附属医院烧伤整形与创面修复医学中心,南昌330006

出　　处：《中华烧伤与创面修复杂志》2023年第2期184-189,共6页Chinese Journal of Burns And Wounds

基　　金：河南省医学科技攻关项目(LHGJ20200700,LHGJ20210714)。

摘　　要：糖尿病创面是糖尿病患者的常见并发症,近年来其发病率不断上升,且临床预后较差,严重影响患者的生活质量,逐渐成为糖尿病治疗的重点和难点。非编码RNA作为调控基因表达的RNA,可调控许多疾病的病理生理过程,在糖尿病创面的愈合过程中起着重要作用。该文对3种常见非编码RNA在糖尿病创面愈合过程中的调控作用、诊断价值、治疗潜力进行了综述,从基因层面和分子水平上为糖尿病创面的诊疗提供了新思路。Diabetic wounds are a common complication of diabetic patients,and the incidence has been increasing in recent years.In addition,its poor clinical prognosis seriously affects the quality of life of patients,which has become the focus and difficulty of diabetes treatment.As the RNA regulating gene expression,non-coding RNA can regulate the pathophysiological process of diseases,and play an important role in the healing process of diabetic wounds.In this paper,we reviewed the regulatory role,diagnostic value,and therapeutic potential of three common non-coding RNA in diabetic wounds,in order to provide a new solution for the diagnosis and treatment of diabetic wounds at the genetic and molecular level.

关 键 词：糖尿病 RNA 长链非编码 伤口愈合 

分 类 号：R632.1[医药卫生—外科学] R34[医药卫生—临床医学]