华西职业性尘肺病队列研究设计及初步结果  

Research design and preliminary results of West China Occupational Pneumoconiosis Cohort Study

作　　者：袁琴 张鹏 张勤 廖加强 姚于勤 史莹 周敏[2] 伏代刚[2] 谢林伸[2] 何秋蓉[4] 伍东升[5] 韩俗[6] 陈荔[7] 孙敏[8] 汪川[10] 姜侠[11] 李佳圆 兰亚佳[3,13] 杨罗 沈江[5] 张本 彭莉君[1,2] YUAN Qin;ZHANG Peng;ZHANG Qin;LIAO Jia-qiang;YAO Yu-qin;SHI Ying;ZHOU Min;FU Dai-gang;XIE Lin-shen;HE Qiu-rong;WU Dong-sheng;HAN Su;CHEN Li;SUN Min;WANG Chuan;JIANG Xia;LI Jia-yuan;LAN Ya-jia;YANG Luo;SHEN Jiang;ZHANG Ben;PENG Li-jun(West China Occupational Pneumoconiosis Cohort Study(WCOPCS)workgroup,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China;不详)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院华西职业性尘肺病队列(West China Occupational Pneumoconiosis Cohort Study,WCOPCS)工作组,四川成都610041 [2]四川大学华西第四医院国家临床重点专科职业病科 [3]华西-协和陈志潜卫生健康研究院职业病防治研究中心 [4]四川大学华西第四医院检验科 [5]四川大学华西第四医院放射科 [6]四川大学华西第四医院信息化建设部 [7]四川大学华西第四医院病案管理部 [8]四川大学华西第四医院门诊办公室 [9]四川大学华西公共卫生学院公共卫生与预防医学实验中心 [10]四川大学华西公共卫生学院卫生检验与检疫学系 [11]四川大学华西公共卫生学院营养与食品卫生学系 [12]四川大学华西公共卫生学院流行病与卫生统计学系 [13]四川大学华西公共卫生学院劳动卫生与环境卫生学系 [14]四川大学华西公共卫生学院/华西第四医院

出　　处：《现代预防医学》2023年第4期586-591,共6页Modern Preventive Medicine

基　　金：国家自然科学基金面上项目(81874283,81773375);四川大学“从0到1”创新研究项目(2022SCUH0027)。

摘　　要：尘肺病是影响我国职业人群健康最主要的职业性肺部疾病,其预防、诊断、治疗和康复尚缺乏系统性的研究,国内外开展的尘肺队列研究多以接尘作为观察起点,以发病或死亡作为结局,缺乏精细化的尘肺病临床队列研究。本课题以国家临床重点专科职业病科为依托,建立华西职业性尘肺病专病队列,以循证医学证据为基础,通过专家论证建立尘肺病队列入组标准,招募尘肺病患者入组,并开展长期随访,收集入组对象的基线信息、职业暴露信息、诊疗信息,同时采集血液、肺灌洗液等生物样本,在此基础上搭建尘肺病队列多模态数据动态采集及管理信息系统。根据大型人群队列终点事件长期随访技术规范,数据安全及数据处理技术规范,中国人类遗传资源管理要求,对队列观察对象开展连续、规范地追踪随访,为尘肺病发病、诊疗及预后的系统性多组学多模态研究提供支撑。精细化的华西职业性尘肺队列还将为尘肺纤维化机制的深入研究、靶向药物开发及尘肺病的精准诊疗提供研究平台。本文主要针对华西职业性尘肺病队列的研究设计和初步结果做简要介绍。Pneumoconiosis is the most serious occupational lung disease in China,and its prevention,diagnosis,treatment,and rehabilitation still lack systematic research.Previous pneumoconiosis cohort studies mostly focused on etiological and determinant factors research based on industrial dust exposure cohort,and lung fibrosis or death was generally an endpoint.There were few precise clinical cohort studies of pneumoconiosis.Therefore,this project aims to establish a clinic cohort for occupational pneumoconiosis based on the national clinical key specialties of occupational diseases.Based on evidence-based medical evidence,the West China Occupational pneumoconiosis cohort study(WCOPCS)was established through expert opinion and consensus criteria,aiming to recruit pneumoconiosis patients.Long-term follow-up programs will be conducted for them.The baseline information,occupational exposure,hospitalization information,and venous blood biological samples of the enrolled pneumoconiosis patients were collected.On this basis,the dynamic collection and management of a multimodal data information system for the West China Occupational Pneumoconiosis Cohort were established.According to the technical specification of long-term follow-up for endpoints,data security,and data processing in a large population-based cohort study,and the management requirements of Chinese genetic resources,the observational patients will be continuously and normatively followed-up,which will assist in the systematic multi-omics and multimodal study of pneumoconiosis incidence,diagnosis,treatment,and prognosis.With the establishment of WCOPCS,it will provide a research platform for the study of fibrotic mechanisms of pneumoconiosis,the development of targeted drugs for pulmonary fibrosis,and precision diagnosis and treatment.This paper is exactly a brief introduction to the research design and primary results of WCOPCS.

关 键 词：尘肺 临床队列 研究设计 

分 类 号：R135.2[医药卫生—劳动卫生]