复发性流产患者转氨酶升高与早期妊娠失败的相关性分析  

Correlation analysis of elevated transaminase and early pregnancy failure in patients with recurrent spontaneous abortion

作　　者：张姝文 李佳钋 徐赫泽 侯悦 乔宠[1] Zhang Shuwen;Li Jiapo;Xu Heze;Hou Yue;Qiao Chong(Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang Liaoning 110000,P.R.China)

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110000

出　　处：《中国计划生育和妇产科》2023年第2期66-72,共7页Chinese Journal of Family Planning & Gynecotokology

基　　金：辽宁省民生科技计划联合计划项目(项目编号:2021JH2/10300123);沈阳市科技计划项目(项目编号:20-2054-004);百千万人才工程领军人才(项目编号:XLYC2005008)。

摘　　要：目的探讨复发性流产(recurrent spontaneous abortion,RSA)患者转氨酶水平与早期妊娠失败的相关性,分析导致转氨酶升高的危险因素,为临床早期干预提供依据。方法选取2017年1月至2018年3月就诊于中国医科大学附属盛京医院产科门诊的妊娠早期RSA患者202例,根据是否发生早期妊娠失败分为妊娠失败组(47例)和对照组(155例),根据转氨酶升高情况分为转氨酶升高组(55例)、转氨酶正常组(147例),分析转氨酶升高与早期妊娠失败的相关性以及转氨酶升高的高危因素。结果与对照组相比,妊娠失败组患者血清转氨酶水平明显升高(P<0.05);妊娠失败组患者转氨酶升高与胚胎染色体异常无关(P>0.05);转氨酶升高组患者妊娠失败率明显高于转氨酶正常组(P<0.05);单因素和多因素分析均提示:血清转氨酶水平升高是RSA患者发生早期妊娠失败的独立危险因素(P均<0.05);单因素分析和多因素回归分析发现仅妊娠早期使用静脉注射丙种球蛋白(IVIG)是RSA患者转氨酶升高的独立危险因素(P<0.05)。结论发生早期妊娠失败的RSA患者血清转氨酶水平显著升高,血清转氨酶水平升高是RSA患者发生早期妊娠失败的独立危险因素,应重视妊娠早期转氨酶升高。妊娠早期用药与转氨酶升高有关,尤其是IVIG,应严格控制妊娠早期IVIG用药指征。Objective To investigate the correlation between transaminase and early pregnancy failure in patients with recurrent spontaneous abortion(RSA)and the risk factors of elevated transaminase,to provide the basis for early clinical intervention.Methods A total of 202 patients with RSA in early pregnancy who were admited to the obstetrics clinic of Shenging Hospital of China Medical Uniwversity from January 2017 to March 2018 were selected.According to the occurrence of early pregnancy failure,they were divided into pregnancy failure group(47 cases)and control group(155 cases).According to the elevation of transaminase,they were divided into transaminase elevation group(55 cases)and transaminase normal group(147 cases).The correlation between transaminase elevation and early pregnancy failure and the high risk factors of transaminase elevation were analyzed.Results Compared with the control group,the serum transaminase level in the pregnancy failure group was significantly increased(P<0.05).The increase of transaminase in the pregnancy failure group was not related to the abnormal chromosome of the embryo(P>0.05).The pregnancy failure rate in the elevated transaminase group was significantly higher than that in the normal transaminase group(P<0.05).Univariate analysis and multivariate analysis both indicated that the elevated serum transaminase level was an independent risk factor for early pregnancy failure in RSA patients(P<0.05),univariate analysis and multivariate regression analysis found that only the use of intravenous gamma globulin(IVIG)in the early pregnancy was an independent risk factor for elevated transaminase in RSA patients(P<0.05).Conclusion Serum transaminase levels are significantly increased in RSA patients with early pregnancy failure.Increased serum transaminase levels are independent risk factors for early pregnancy failure in RSA patients.Attention should be paid to the elevation of transaminase in early pregnancy.Medication in early pregnancy is associated with elevated transaminases,especiall

关 键 词：复发性流产 转氨酶升高 早期妊娠失败 药物使用 

分 类 号：R714.21[医药卫生—妇产科学]