纳米材料在激光解吸电离质谱技术中的应用进展  

Application Advance of Nanomaterials in Laser Desorption/Ionization Mass Spectrometry

作　　者：王闯 覃露媛 李冬梅 薛晋娟[2] 郭磊 唐丽 WANG Chuang;QIN Lu-Yuan;LI Dong-Mei;XUE Jin-Juan;GUO Lei;TANG Li(Key Laboratory of Ethnicmedicine,College of Pharmacy,Minzu University of China,Beijing 100081,China;State Key Laboratory of Toxicology and Medical Countermeasures,Institute of Toxicology and Pharmacology,Academy of Military Medical Sciences,Beijing 100850,China;State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center far Eco-Erwironmental Sciences,Chinese Academy of Sciences,Beijing 100085,China)

机构地区：[1]中央民族大学药学院,民族医药教育部重点实验室,北京100081 [2]军事科学院军事医学研究院毒物药物研究所,抗毒药物与毒理学国家重点实验室,北京100850 [3]中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京100085

出　　处：《分析化学》2023年第2期172-183,I0001-I0004,共16页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.21974152,81873397,22104149)资助。

摘　　要：近年来,基于纳米材料的激光解吸/电离质谱(LDI-MS)技术发展迅速。由于纳米材料具有激光吸收能量转移效率高、比表面积大、易功能化修饰、自身不易电离等特性,因此,LDI-MS技术具备灵敏、快速、高通量和谱图背景相对纯净等优点。本文针对近十年来基于碳基纳米材料、硅基纳米材料、金属有机框架、共价有机框架、金属基纳米材料等的LDI-MS在生物医学分析中的检测应用现状进行了分类和简要评述,并基于分析物种类和灵敏度等因素,比较了各类纳米材料的多种改性或复合途径的影响,聚焦于内外源代谢物空间分布的适用性,简要论述了各类纳米材料在质谱成像中的应用进展,最后阐述了该领域的重点、难点问题以及发展前景。Nanomaterial-based laser desorption/ionization mass spectrometry(LDI-MS)technique has emerged and bloomed in recent years.Taking the advantages of nanomaterials,including high laser desorption and transfer efficiency,large specific surface area,and inert ionization,LDI-MS owned the cutting-edge advances such as high sensitivity,speediness,high throughput,and clean spectrum background.This review summarizes the application advances of nanomaterials in LDI-MS in biomedical analysis over the past 10 years,categorized by carbon-based nanomaterials,silicon-based nanomaterials,metal-organic frameworks,covalent organic frameworks,and metalbased nanomaterials.It compares the influence of different functionalization or composite material on the issues containing sensitivity and analyte kinds,and briefly illustrates the application of various nanomaterials on mass spectrometric imaging techniques that focuses on the applicability of the spatial distribution of internal and external metabolites.Finally,the key issues and prospects of this field are depicted.

关 键 词：激光解吸电离质谱 基质 纳米材料 生物医学样品 质谱成像 评述 

分 类 号：O657.63[理学—分析化学] TB383.1[理学—化学]