超声造影血管周围灌注与急性深静脉血栓形成患者炎性因子水平的相关性  

Correlation of perivascular perfusion by contrast-enhanced ultrasound with inflammatory response in patients with acute deep venous thrombosis

作　　者：李煜 许芸 宋一凡 Li Yu;Xu Yun;Song Yifan(Department of Ultrasound,Beijing Electric Power Hospital,Beijing 100073,China)

机构地区：[1]北京电力医院超声诊断科,北京100073

出　　处：《血管与腔内血管外科杂志》2023年第1期84-87,98,共5页Journal of Vascular and Endovascular Surgery

基　　金：西城区财政科技专项项目(XCSTS-SD2019-04)。

摘　　要：目的 探讨超声造影血管周围灌注与急性深静脉血栓形成(DVT)患者炎性因子水平的相关性。方法 收集2017年6月至2020年6月于北京电力医院就诊的79例DVT患者的临床资料,比较患者入组时(T_(0))、DVT发作后2周(T_(1))、DVT发作后3个月(T_(2))超声造影指标及炎性因子水平。记录患者患肢、健肢超声造影参数,分析炎性因子水平与DVT患肢超声造影参数的相关性。结果 T_(0)、T_(1)、T_(2)时,患肢峰值强度(PE)、流入相比率(Wi R)、流出相比率(WoR)均高于健肢,患肢上升时间(RT)、局部通过时间(mTTI)均低于健肢,差异均有统计学意义(P﹤0.05)。患肢PE、Wi R、WoR、RT、mTTI不同时间两两比较,差异均有统计学意义(P﹤0.05)。T_(1)时,超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-6、IL-8水平均低于T_(0)时;T_(2)时,hs-CRP、IL-6、IL-8水平均低于T_(0)和T_(1)时,差异均有统计学意义(P﹤0.05)。T_(0)、T_(1)、T_(2)时,超声造影相关参数PE、Wi R、WoR与hs-CRP、IL-6、IL-8水平均呈正相关,RT、mTTI与hs-CRP、IL-6、IL-8水平均呈负相关(P﹤0.05)。结论 在超声检查的基础上增加造影,既可直接评估腔内血栓,又可直接评估血栓引起的局部血管周围炎症,可为降低血栓后综合征(PTS)发生率提供参考。Objective To investigate the correlation of perivascular perfusion by contrast-enhanced ultrasound with inflammatory response in patients with acute deep venous thrombosis (DVT).Method The clinical date of 79 DVT patients treated in Beijing Electric Power Hospital from June 2017 to June 2020 were selected.Contrast-enhanced ultrasound indexes and inflammatory indexes at enrolling time (T_(0)),2 weeks (T_(1)) after DVT attack and 3 months (T_(2))were compared,the contrast-enhanced ultrasound indexes of affected extremity and healthy extremity were recorded,the correlation of contrast-enhanced ultrasound indexes with inflammatory indexes were analyzed.Result At T_(0),T_(1)and T_(2),peak enhancement (PE),wash-in rate (WiR) and wash-out rate (WoR) of affected extremity were higher than those of healthy extremity,rise time (RT) and mean transit time local (mTTI) levels of affected extremity were lower than those of healthy extremity,the differences were statistically significant (P<0.05).There were significant differences for PE,Wi R,WoR,RT and mTTI of affected extremity at T_(0),T_(1)and T_(2),the differences were statistically significant (P<0.05).The levels of hs-CRP,IL-6 and IL-8 at T_(1)were higher than those at T_(0),and the levels of hs-CRP,IL-6 and IL-8 at T_(2)were higher than those at T_(0)and T_(1),the differences were statistically significant (P<0.05).At T_(0),T_(1),T_(2),contrastenhanced ultrasound related indexes PE,WiR,WoR were positively correlated with hs-CRP,IL-6 and IL-8,while RT and mTTI were negatively correlated with hs-CRP,IL-6 and IL-8,the differences were statistically significant (P<0.05).Conclusion Contrast-enhanced ultrasound on the basis of ultrasound examination can not only directly evaluate the endovascular thrombosis,but also directly evaluate the local perivascular inflammatory caused by thrombotic events,which can provide reference for reducing occurrence of post thrombotic syndrome (PTS).

关 键 词：深静脉血栓形成 超声造影 炎症反应 血管周围灌注 

分 类 号：R543[医药卫生—心血管疾病]