半夏厚朴汤治疗呼吸系统疾病研究进展  

Treatment of Respiratory Diseases with Banxia Houputang: A Review

作　　者：安继仁 杨新栎 宋纪显 陈琦 贾翠玲 孙梦凡 赵亚硕[1] 吉恩生 AN Jiren;YANG Xinyue;SONG Jixian;CHEN Qi;JIA Cuiling;SUN Mengfan;ZHAO Yashuo;JI Ensheng(Hebei University of Chinese Medicine,Shijiazhuang 050200,China;Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]河北中医学院,石家庄050200 [2]辽宁中医药大学,沈阳110847

出　　处：《中国实验方剂学杂志》2023年第5期236-245,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金青年基金项目(82004127);河北省自然科学基金优秀青年基金项目(C2019423117);河北省中医药管理局科研计划项目(202111)。

摘　　要：呼吸系统疾病是一类临床常见病、多发病,且患病率逐年递增,日益成为严重影响公共卫生健康的问题。中医辨证其主要病位在肺,“肺主气,司呼吸”又为“储痰之器”,临床常以“痰”“气”见治。半夏厚朴汤出自《金匮要略》,最早主治“梅核气”,全方由半夏、厚朴、茯苓、生姜、紫苏叶组成,痰气交阻为此方所治核心病机,具有行气散结,降逆化痰之功效,这正与肺脏的病理特性基本相应。临床研究证实,半夏厚朴汤原方加减用药,或单独应用,或与西药联合应用治疗慢性咽炎、哮喘、慢性阻塞性肺疾病、肺炎、阻塞性睡眠呼吸暂停及上气道咳嗽综合征等呼吸系统疾病具有显著效果,可有效改善疾病症状体征、降低复发率等。基础研究表明,其可通过调节多通路靶点起到抗炎、抗氧化应激、抗凋亡、调节自噬、调节铁超载等作用。该文通过梳理近年来相关文献,就半夏厚朴汤方证探析、临床治疗研究及作用机制研究等三方面进行了系统综述,以期为该方治疗呼吸系统疾病的作用机制研究并扩展其临床应用提供理论依据和参考。Respiratory diseases are common,frequently-occurring clinical diseases.As the prevalence rate is increasing year by year,they have become a problem that seriously affects public health.The diseases are mainly located in the lung by traditional Chinese medicine(TCM)syndrome differentiation.Lung governs Qi and controls breathing and is also an organ for the storage of phlegm.Clinically,phlegm and Qi are often used for the treatment.Banxia Houputang(BHT),originated from Synopsis of the Golden Chamber(《金匮要略》),was used to treat plum-stone Ai(globus hystericus)at first.It is composed of Rhizoma Pinelliae,Cortex Magnoliae Offcinalis,Poria,Rhizoma Zingiberis Recens,and Folium Perillae,and treats diseases with the core pathogensis of mutual obstruction of phlegm and Qi.BHT has the effects of moving Qi,dissipating mass,descending adverse Qi,and resolving phlegm,which basically correspond to the pathological characteristics of the lungs.Clinical studies have confirmed that modified BHT can be used either alone or in combination with western medicine to treat chronic pharyngitis,asthma,chronic obstructive pulmonary disease,pneumonia,obstructive sleep apnea,upper airway cough syndrome and other respiratory diseases,with significant effects.It effectively improves the symptoms and signs of the diseases and reduces the recurrence rate.Basic research has shown that BHT plays anti-inflammatory,anti-oxidative stress,anti-apoptotic,autophagy-regulating,and iron overload-regulating roles by regulating the targets in multiple pathways.This paper,by combing the relevant literature in recent years,conducted a systematic review on BHT from the three aspects of syndrome analysis,clinical treatment research and mechanism research,with a view to providing theoretical basis and reference for the mechanism research of BHT in treating respiratory diseases and for expanding its clinical application.

关 键 词：半夏厚朴汤 异病同治 呼吸系统疾病 辨证论治 药理作用 临床应用 综述 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33