芪参还五胶囊治疗气血亏虚型帕金森病的临床效果  

Clinical effect of Qishenhuanwu Capsules on Parkinson’s disease with qi and blood deficiency

作　　者：王雯[1] 邱志新[1] 郑建彪[1] 景海芳 王爱卿[1] 刘东方 李宁[1] 王颖利[2] WANG Wen;QIU Zhixin;ZHENG Jianbiao;JING Haifang;WANG Aiqing;LIU Dongfang;LI Ning;WNAG Yingli(The Second Department of Encephalopathy,Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Hebei Province,Changzhou 061000,China;Teaching and Research Section of Internal Medicine,Cangzhou Medical College,Hebei Province,Changzhou 061001,China)

机构地区：[1]河北省沧州中西医结合医院脑病二科,河北沧州061000 [2]河北省沧州医学高等专科学校内科教研室,河北沧州061001

出　　处：《中国医药导报》2023年第5期67-70,74,共5页China Medical Herald

基　　金：河北省中医药管理局科研计划项目(2019296)。

摘　　要：目的探究芪参还五胶囊治疗气血亏虚型帕金森病(PD)的临床效果。方法选择2020年3月至2022年1月河北省沧州中西医结合医院收治的气血亏虚型PD患者100例,并用随机数字表法分为对照组(常规药物治疗,50例)和试验组(常规药物治疗联合芪参还五胶囊,50例),两组共持续治疗6周。比较两组临床效果、治疗前后运动及非运动症状、相关实验室指标的差异。结果试验组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组简易智能精神状态评价量表、蒙特利尔认知评估量表评分高于治疗前,且试验组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组PD评定量表Ⅲ、PD非运动症状问卷评分低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清胰岛素样生长因子、β-淀粉样蛋白1-42高于治疗前,且试验组高于对照组;两组同型半胱氨酸、C反应蛋白低于治疗前,且试验组低于对照组比较,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论芪参还五胶囊治疗气血亏虚型PD可有效改善运动及非运动症状,效果显著。Objective To explore the clinical effect of Qishenhuanwu Capsules in treating Parkinson’s disease(PD)with Qi and blood deficiency.Methods A total of 100 PD patients with Qi and blood deficiency admitted to Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from March 2020 to January 2022 were selected and divided into control group(conventional drug treatment,50 cases)and experimental group(conventional drug treatment combined with Qishenhuanwu Capsules,50 cases)by random number table method.The two groups were treated for a total of six weeks.The clinical effects,motor and non-motor symptoms before and after treatment,and related laboratory indicators were compared between the two groups.Results The clinical efficacy of the experimental group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of the Simple Intelligent Mental State Assessment Scale and the Montreal Cognitive Assessment Scale in the two groups were higher than before treatment,while those of the experimental group were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,PD rating scaleⅢand PD non-motor symptom questionnaire scores of the two groups were lower than before treatment,and those of the experimental group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,serum insulin-like growth factor andβ-amyloid 1-42 in two groups were higher than before treatment,while those of the experimental group were higher than those of the control group;homocysteine and C-reactive protein in the two groups were lower than before treatment,while those of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Qishenhuanwu Capsules can effectively improve moto

关 键 词：芪参还五胶囊 气血亏虚型 帕金森病 运动症状 非运动症状 

分 类 号：R277.7[医药卫生—中医学]