Pervasive Translation of Circular RNAs  

出　　处：《Bulletin of the Chinese Academy of Sciences》2022年第2期71-72,共2页中国科学院院刊（英文版）

摘　　要：Circular RNAs(circRNAs)are prevalent in animals and plants and are created through the back-splicing of pre-mRNAs.Previously thought to be by-products,the discovery of circRNA’s hidden roles in gene regulation has led to a greater understanding of their importance.These molecules may act as molecular sponges by sequestering miRNAs or RNA binding proteins,or may promote the transcription of nearby genes.Recent research has shown that circRNAs require the internal ribosomal entry site(IRES)for translation in a capindependent mechanism due to the lack of a 5’end.However,the research community does not share a common opinion on the existence of IRESs in eukaryotic transcriptomes,casting doubts on the scope of circRNA translation.

关 键 词：DOUBT SPONGE NEARBY 

分 类 号：Q752[生物学—分子生物学]