左氧氟沙星致横纹肌溶解症的临床特征分析  

Analysis of Clinical Characteristics of Levofloxacin-induced Rhabdomyolysis

作　　者：潘娟 周玲芝[1] 钟菁[1] 聂格 张旭 李足意 PAN Juan;ZHOU Ling-zhi;ZHONG Jing;NIE Ge;ZHANG Xu;LI Zu-yi(Department of Pharmacy,Liuyang Hospital of Traditional Chinese Medicine,Liuyang Hunan 410300,China)

机构地区：[1]浏阳市中医医院药学部,湖南浏阳410300

出　　处：《抗感染药学》2022年第10期1465-1470,共6页Anti-infection Pharmacy

基　　金：浏阳市中医医院2019年度院级科研基金课题(编号:2019009)。

摘　　要：目的:分析左氧氟沙星所致横纹肌溶解症(rhabdomyolysis,RM)的临床特点,为左氧氟沙星的临床用药安全提供参考。方法:以“左氧氟沙星“”横纹肌溶解“”肌痛“”levofloxacin“”rhabdomyolysis“”myopathy”为关键词,在中国知网、万方、重庆维普、中国生物医学文献数据库、PubMed、Embase、Web of Science等国内外数据库中检索截至2021年10月的相关文献,采集文献中左氧氟沙星致RM患者的相关临床资料,分析左氧氟沙星所致RM的临床特点。结果:在国内外数据库中共检索到17篇左氧氟沙星致RM的相关文献,涉及患者17例(男12例,女6例),其中≥60岁者11例;17例患者中,用药原因主要为肺部感染(10例),给药途径主要为口服给药(10例),有5例患者存在超说明书剂量用药;使用左氧氟沙星至发生RM的潜伏期为3 h~19 d,其中潜伏期<10 d的有13例;RM的临床表现主要有肌痛(13例)和肌无力(11例),其间患者血清肌酸激酶水平最高为451~159450 U/L;在对症治疗后,好转或痊愈的有15例。结论:左氧氟沙星引起的RM在男性和老年患者出现较多,其潜伏期多在10 d内,在对症治疗后绝大多数患者好转或痊愈。Objective:To analyze the clinical characteristics of levofloxacin-induced rhabdomyolysis(RM),so as to provide reference for the safety of clinical medication of levofloxacin.Methods:By using"levofloxacin","rhabdomyolysis"and"myopathy"as keywords,the relevant literatures up to October 2021 were searched from domestic and foreign databases such as CNKI,Wanfang,Chongqing VIP,SinoMed,PubMed,Embase,Web of Science,relevant clinical data of patients with levofloxacin-induced RM were collected,and the clinical characteristics of levofloxacininduced RM were analyzed.Results:A total of 17 literatures related to levofloxacin-induced RM were searched from domestic and foreign databases,involving 17 patients(12 males and 6 females),including 11 patients greater than or equal to 60 years old.Among the 17 patients,the main cause of medication was pulmonary infection(10 patients),the main route of administration was oral administration(10 patients),and there were 5 patients with overdose of medication.The latent period from the use of levofloxacin to the occurrence of RM was 3 hours to 19 days,including 13 patients with a latent period of less than 10 days.The clinical manifestations of RM mainly included myalgia(13 patients)and muscle weakness(11 patients),and the highest serum CK level was 451-159450 U/L;after symptomatic treatment,15 patients were improved or recovered.Conclusion:Levofloxacin-induced RM is more common in male and elderly patients,and the latent period is mostly within 10 days.Most patients are improved or recovered after symptomatic treatment.

关 键 词：左氧氟沙星 横纹肌溶解 药物不良反应 临床特点 

分 类 号：R969.3[医药卫生—药理学]