HPV不同亚型对产后出血与新生儿结局的影响  

Effects of Different HPV Subtypes on Postpartum Hemorrhage and Neonatal Outcomes

作　　者：张晓燕 邸玥莹 ZHANG Xiao-yan;DI Yue-ying(Army 73rd Group Hospital of the PLA,Fujian Xiamen 361000)

机构地区：[1]陆军第73集团军医院,福建厦门361000

出　　处：《深圳中西医结合杂志》2023年第1期34-36,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨人乳头瘤病毒(HPV)不同亚型对产后出血与新生儿结局的影响。方法:选取2020年1月至2021年12月在陆军第73集团军医院分娩的230例HPV感染产妇资料,根据产前HPV分型将全部产妇划分为普通组(136例)与高危组(94例)。比较两组产妇妊娠结局、产后情况、新生儿结局及HPV传染情况。结果:高危组产妇孕早期自然流产、早产、胎膜早破、胎儿宫内生长受限的发生率均高于普通组,产后出血发生率与产褥期感染率均高于普通组,羊水、脐带血、胎盘及胎儿咽候分泌物HPV阳性率,新生儿HPV感染率均高于普通组,差异均具有统计学意义(P <0.05);两组新生儿的胎儿窘迫发生率及新生儿呼吸窘迫、新生儿黄疸发生率比较,差异均无统计学意义(P> 0.05)。结论:HPV高危亚型可导致产妇产后出血与产褥期感染发生率升高,且母婴间垂直传染风险更高,但对于新生儿不良结局未见明显影响。Objective To investigate the effect of different subtypes of human papillomavirus(HPV)on postpartum hemorrhage and neonatal outcomes.Methods A total of 230 HPV-infected parturients who delivered in the 73rd Military Hospital of the Army from January 2020 to December 2021 were selected.All the patients were divided into ordinary group(136 cases)and high-risk group(94 cases)according to prenatal HPV typing.The pregnancy outcomes,postpartum conditions,neonatal outcomes and HPV infection were compared between the two groups.Results The incidences of spontaneous abortion,premature delivery,premature rupture of membranes,and fetal intrauterine growth restriction in the high-risk group were higher than those in the ordinary group,and the incidences of postpartum hemorrhage and puerperium infection were higher than those in the ordinary group.The positive rates of HPV in amniotic fluid,umbilical cord blood,placenta,and fetal pharyngeal secretions,and the neonatal HPV infection rate were higher than those in the ordinary group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of fetal distress,neonatal respiratory distress,and neonatal jaundice between the two groups(P>0.05).Conclusion High-risk subtypes of HPV can increase the incidence of postpartum hemorrhage and puerperium infection,and the risk of vertical transmission between mother and child is higher,but there is no significant effect on adverse neonatal outcomes.

关 键 词：人乳头瘤病毒亚型 产后出血 新生儿结局 

分 类 号：R714.7[医药卫生—妇产科学]