肺动脉栓塞检测的可视中国人蒙特卡罗模拟分析  

Visible Chinese Human for Pulmonary Embolism Detection of Monte Carlo Simulation Analysis

作　　者：王敏[1] 孟硕 郭江辉 李婷 Wang Min;Meng Shuo;Guo Jianghui;Li Ting(School of Life Sciences,Tiangong University,Tianjin 300387,China;Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin300192,China;School of Optoelectronic Science and Engineering,University of Electronic Science&Technology of China,Chengdu 611731,Sichuan,China;Chinese Institute forBrain Research,Beijing,Beijing 102206,China)

机构地区：[1]天津工业大学生命科学学院,天津300387 [2]中国医学科学院北京协和医学院生物医学工程研究所,天津300192 [3]电子科技大学光电科学与工程学院,四川成都611731 [4]北京脑科学与类脑研究中心,北京102206

出　　处：《中国激光》2022年第24期53-59,共7页Chinese Journal of Lasers

基　　金：国家自然科学基金面上项目(81971660);天津杰出青年基金(20JCJQIC00230);北京脑科学与类脑研究中心科研合作项目(2020-NKX-XM-14);四川省科技项目(2021YFH0004);中国医学科学院医学与健康科技创新工程(2021-I2M-1-042,2021-I2M-1-058)。

摘　　要：肺动脉数字减影血管造影技术是现阶段临床检测肺动脉栓塞的主要手段,但该技术是一种有创的检查,且易对血管及周围组织造成损伤。在目前的心血管医学研究中,肺动脉栓塞的无创检测具有一定挑战性。本课题组运用蒙特卡罗方法模拟研究了光在人体胸部组织中的传输规律,探讨了近红外光谱技术在肺动脉栓塞无创检测中的可能性。结果表明:在2.8~3.1 cm的光源与探测器距离下,检测到信号对肺动脉部位激活的灵敏度可达到0.073%的峰值;不同栓塞水平下的归一化光照强度差异显著,且二者之间呈线性关系(R2=0.998,p<10-5)。这些结果表明,近红外光谱技术在肺动脉栓塞定量检测中具有巨大潜力。本研究为无创光学方法诊断肺动脉栓塞提供了参考。Objective Pulmonaryembolism(PE)is a clinical and pathophysiological syndrome in which an endogenous or exogenous embolus occludes the pulmonary artery or its branches,causing pulmonary circulatory impairment that can lead to severe pulmonaryinfarction,usually accompanied by cardiovascular disease.Currently,the most accurate method for detecting PE is digital subtraction angiography(DSA)of the pulmonary arteries.However,this detection method is invasive and can easily damage blood vessels or surrounding tissues and often causes additional complications.Therefore,non-invasive,real-time,and accurate detection of pulmonary artery hemodynamics is highly desirable.Near-infrared spectroscopy(NIRS)is a simple,rapid,portable,and relatively inexpensive technique for non-invasive deep-tissue hemodynamic monitoring,which is based on the spectral characteristics of oxyhemoglobin(HbO2)and deoxyhemoglobin(Hb),which are characteristics used to quantify tissue hemoglobin oxygen saturation for disease measurement.In recent years,an increasingnumber of research groups have chosen to use NIRS to monitor human diseases,and it has been validated for use in studies involving many tissue sites in the body.However,the study of photons in the human pulmonary artery site has not been conducted in depth.Therefore,the feasibility of using NIRS to detect pulmonary artery embolism is investigatedin this study.Methods Inthis study,we used 80 photographic images from the Visual Chinese Human(VCH)dataset slices to map the thoracic tissue region of the pulmonary artery from top to bottom to build a 436×420×80 voxel thoracic photographic model(Figure 1).Each voxel is defined as a 0.4 mm×0.4mm×0.4mm cube.The entire model is divided into eight partsbased on tissue type,including skin,muscle,bone,subcutaneous fat,lung,pulmonary artery,arterial blood,and venous blood.The constructed model is then loaded into a software program developed by our team for Monte Carlo simulation of light propagation in Voxelated Media(MCVM).MCVM generates two files:a p

关 键 词：医用光学 肺动脉栓塞 近红外光谱技术 蒙特卡罗模拟 无创检测 

分 类 号：TP391.9[自动化与计算机技术—计算机应用技术]