基于谱域偏振敏感光学相干层析的局域偏振属性提取及生物组织烧伤深度的定量测量  

Local Polarization Properties Extraction Based on Spectral Domain Polarization Sensitive Optical Coherence Tomography and Quantitative Burn Depth Measurement of Biological Tissues

作　　者：吴彤 周鑫康 刘友文[2] 王吉明[2] 路元刚 沈红[3] 顾晓蓉[2] 施瑶瑶 赫崇君 Wu Tong;Zhou Xinkang;Liu Youwen;Wang Jiming;Lu Yuangang;Shen Hong;Gu Xiaorong;Shi Yaoyao;He Chongjun(Key Laboratory of Space Photoelectric Detection and Perception,Ministry of Industry and Information Technology,College of Astronautics of Nanjing University of Aeronautics and Astronautics,Nanjing 211106,Jiangsu,China;College of Physics Nanjing University of Aeronautics and Astronautics,Nanjing 211106,Jiangsu,China;Jiangsu Key Laboratory of Oral Diseases Department of Pediatric and Preventive Dentistry,Affiliated Hospital of Stomatology,Nanjing Medical University,Nanjing 211106,Jiangsu,China)

机构地区：[1]南京航空航天大学空间光电探测与感知工业和信息化部重点实验室,南京航空航天大学航天学院,江苏南京211106 [2]南京航空航天大学物理学院,江苏南京211106 [3]南京医科大学江苏省口腔疾病研究重点实验室,南京医科大学附属口腔医院儿童口腔预防科,江苏南京211106

出　　处：《中国激光》2022年第24期88-96,共9页Chinese Journal of Lasers

基　　金：国家自然科学基金(62175106,62105146)。

摘　　要：本文提出了一种基于谱域偏振敏感光学相干层析(SD-PSOCT)成像系统的局域偏振属性提取算法,并将其用于生物组织烧伤深度的定量测量。该SD-PSOCT系统采用全单模光纤器件,使用光纤型偏振控制器实现单偏振态入射样品,利用线性波数光谱仪实现偏振敏感探测,基于逐层迭代算法恢复局域偏振属性信息。测量了四分之一波片的相位延迟和光轴方位角,重建了不同程度烧伤牛腱组织的OCT强度图像、累积相位延迟层析图像、累积光轴方位角层析图像、局域相位延迟层析图像和局域光轴方位角层析图像。基于局域相位延迟层析图像定量测量了不同程度烧伤牛腱组织的烧伤深度,验证了该系统用于定量测量生物组织烧伤深度的可行性和临床应用潜力。Objective Quantitative measurement of burn depth is of great significance for the clinical assessment of burn degree and t reatment plan.Currently,the most widely used assessment method is visual inspection,which places high demands on doctors’experience and is easily influenced by subjective judgment.Other detection techniques,such as laser Doppler i maging,ultrasound imaging,and fluorescence imaging,have also been used to assess the extent of burns;however,these techniques cannot non-invasively and accurately measure burn depth.Polarization-sensitive optical coherence tomography(PSOCT)has the advantages of non-invasiveness,fast imaging speed and high resolution and can quantitatively measure the burn depth based on the polarization information of the burned tissue.However,the traditional measurement method is based on the accumulated polarization information from the sample surface to a certain depth inside the sample,which cannot accurately characterize the local polarization information at this depth;hence,the burn depth cannot be accurately measured.Therefore,this study proposes a local polarization information extraction algorithm based on spectral domain polarization-sensitive optical coherence tomography(SD-PSOCT)to obtain polarization information at each depth inside the burned biological tissue to quantitatively measure the burn depth of the biological tissue.Methods A local polarization property extraction algorithm based on the SD-PSOCT system was proposed and used to quantitativel y measure the burn depth of biological tissue.All single-mode-fiber-based systems adopt fiber-based polarization controllers to illuminate a sample with a single-input polarization state.A custom-built linear-in-wavenumber spectrometer consisting of a diffraction grating,dispersive prism,Wollaston prism,and a focusing lens was used to realize polarization-sensitive detection(Fig.2).Then,the local phase retardation and axis orientation of each layer of the sample were calculated by eigenvalue decomposition based on the Jon

关 键 词：医用光学 偏振敏感探测 光学相干层析成像 局域偏振属性提取 烧伤深度测量 

分 类 号：TN247[电子电信—物理电子学]