A pH-responsive biomimetic drug delivery nanosystem for targeted chemo-photothermal therapy of tumors  

作　　者：Yanmin Ju Zhiyi Wang Zeeshan Ali Hongchen Zhang Yazhou Wang Nuo Xu Hui Yin Fugeng Sheng Yanglong Hou 

机构地区：[1]Beijing Key Laboratory for Magnetoelectric Materials and Devices(BKL-MMD),Beijing Innovation Centre for Engineering Science and Advanced Technology(BIC-ESAT),School of Materials Science and Engineering,Peking University,Beijing 100871,China [2]College of Pharmacy,China Pharmaceutical University,Nanjing 211198,China [3]Synthetic and Functional Biomolecules Center,Department of Chemical Biology,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China [4]Fifth Medical Center of Chinese PLA General Hospital,Beijing 100071,China

出　　处：《Nano Research》2022年第5期4274-4284,共11页纳米研究（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(Nos.52027801,51631001,and 52002402);the National Key R&D Program of China(No.2017YFA0206301);the Natural Science Foundation of Beijing Municipality(No.2191001),and the China-German Collaboration Project(No.M-0199);the Natural Science Foundation of Jiangsu Province(No.BK20200574)。

摘　　要：Smart drug delivery nanosystem is significant for tumor treatments due to its possibility of temporally,spatially,and dose-controlled release.However,the therapeutic efficacy of drug delivery nanosystem is often compromised in cancer treatment as the enrichment of therapeutic agents in the reticuloendothelial system.Herein,doxorubicin(DOX)loaded biomimetic drug delivery nanosystem with macrophage cell membrane(MCM)camouflaged,MnFe_(2)O_(4)-DOX-MCM nanocube(NC),is developed for cancer treatment with tumor targeting,pH-stimuli drug release,and chemo-photothermal therapeutic effects.The nanosystem shows the capability of immune escape and enhanced cellular uptake of cancer cells due to the MCM decoration.Acid-labile bond between the MnFe2O4 NCs and DOX remains stable at physiological condition and release drugs immediately in response to the endo-/lysosome pH stimuli.Meanwhile,the photothermal effect of the nanosystem destroys tumor tissue,which further promotes chemotherapeutic efficacy.In vivo results demonstrate the tumor homing ability and produce a notable synergistic therapeutic effect of the NCs.Thus,biomimetic pH-responsive drug delivery nanosystem,MnFe_(2)O_(4)-DOX-MCM NCs,is an effective nanoplatform,which might be potential application for cancer synergistic treatment.

关 键 词：drug delivery macrophage cell membrane pH stimuli synergistic therapy 

分 类 号：TB383[一般工业技术—材料科学与工程]