头孢唑林钠致孕产妇全身性过敏反应1例分析  

Analysis of one case of anaphylaxis caused by cefazolin sodium in pregnant women

作　　者：张鑫 陶东红 万齐华 Xin ZHANG;Dong-Hong Tao;Qi-Hua WAN(Department of Pharmacy,Xining First People's Hospital,Xining 810000,China)

机构地区：[1]西宁市第一人民医院药学部,西宁810000

出　　处：《药物流行病学杂志》2023年第1期107-110,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：分析1例头孢唑林致孕产妇全身性过敏反应的诊疗经过,结合文献检索,探讨头孢唑林致全身性过敏反应的特点和应对措施。1例27岁孕产妇使用注射用头孢唑林钠30 s后出现手脚发麻,胸闷、憋气、呼吸困难,呕吐,全身皮肤紫绀,胎心降低,立即停用头孢唑林,予左侧卧位并给予地塞米松磷酸钠注射液、盐酸肾上腺素注射液、补液等对症治疗后,患者生命体征平稳,转重症医学科继续救治,后患者未再使用头孢唑林,2 d后患者、新生儿生命体征平稳。头孢唑林致孕产妇全身性过敏反应时应立即停药,需注意使患者保持左侧卧位、维持子宫胎盘血流灌注、监测胎心率、辅助供氧及液体复苏等。The process of diagnosing and treating one case of anaphylaxis induced by cefazolin in pregnant women was analyzed.The characteristics by which cefazolin induced anaphylaxis was studied with reference to literature.After 30 seconds of using cefazolin sodium for injection,a 27-year-old pregnant woman developed numbness in hands and feet,chest tightness,suffocation,dyspnea,vomiting,skin cyanosis and fetal heart rate depression.Cefazolin was immediately stopped,left lying position was given,dexamethasone sodium phosphate injection,epinephrine hydrochloride injection,fluid infusion and other symptomatic treatments were given.After symptomatic treatment,the patient’s vital signs were stable.The patient was transferred to the department of critical care medicine for further treatment.Later,the patient was not using cefazolin.Two days later,the patient’s and newborn’s vital signs were stable.The use of cefazolin in pregnant womenn should be stopped immediately after the occurrence of anaphylaxis,and attention should be paid to keep the patient in the left lateral position,maintain uterine placental perfusion,monitoring of fetal heart rate,auxiliary oxygen and fluid resuscitation.

关 键 词：头孢唑林钠 孕产妇 全身性过敏 病例报告 

分 类 号：R969[医药卫生—药理学]